144823-64-3Relevant articles and documents
Studies Toward a Model for Predicting the Diastereoselectivity in the Electrophilic Amination of Chiral 1,3,2-Oxazaphospholanes
Jommi, Giancarlo,Miglierini, Giuliana,Pagliarin, Roberto,Sello, Guido,Sisti, Massimo
, p. 7275 - 7288 (2007/10/02)
A model has been developed for predicting the diastereoselectivity in the electrophilic amination of chiral 1,3,2-oxazaphospholanes derived from ephedrine and pseudoephedrine derivatives.The influence of the five-membered ring conformations and of the bulkiness of the ring substituents has been deeply analyzed both for reactivity prediction and for 1H-NMR data interpretation.The theoretical and experimental results are in good agreement.