1449763-02-3

Basic information

• Product Name: 1-(4-(3-chloropropoxy)-5-methoxy-2-nitrophenyl)-3-(dimethylamino)propyl-2-en-1-one
• Synonyms: 1-(4-(3-chloropropoxy)-5-methoxy-2-nitrophenyl)-3-(dimethylamino)propyl-2-en-1-one
• CAS NO: 1449763-02-3
• Molecular Weight: 342.779
• Mol File: 1449763-02-3.mol
• Article Data: 30

Chemical Properties

• CAS DataBase Reference: 1-(4-(3-chloropropoxy)-5-methoxy-2-nitrophenyl)-3-(dimethylamino)propyl-2-en-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-(3-chloropropoxy)-5-methoxy-2-nitrophenyl)-3-(dimethylamino)propyl-2-en-1-one(1449763-02-3)
• EPA Substance Registry System: 1-(4-(3-chloropropoxy)-5-methoxy-2-nitrophenyl)-3-(dimethylamino)propyl-2-en-1-one(1449763-02-3)

Safety Data

• Hazardous Substances Data: 1449763-02-3(Hazardous Substances Data)

Upstream product

• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 127-19-5 N,N-dimethyl acetamide 
• 1160707-44-7 1-[4-(3-chloropropoxy)-5-methoxy-2-nitrophenyl]ethan-1-one 
• 498-02-2 1-(3-methoxy-4-hydroxyphenyl)ethanone 
• 58113-30-7 4-(3-chloropropoxy)-3-methoxyacetophenone 

Downstream Products

• 1428787-51-2 (E)-N⁴-(3-fluoro-4-(6-methoxy-7-(3-(piperidin-1-yl)propoxy)quinoline-4-yloxy)phenyl)-N¹-(benzylidene)semicarbazide 
• 1449763-26-1 (E)-N¹-(3-fluoro-4-(6-methoxy-7-(3-(piperidin-1-yl)propoxy)quinolin-4-yloxy)phenyl)-N⁴-(4-chlorobenzylidene)semicarbazide 
• 1428787-48-7 (E)-N⁴-(3-fluoro-4-(6-methoxy-7-(3-(4-methylpiperidin-1-yl)propoxy)quinoline-4-yloxy)phenyl)-N¹-(benzylidene)semicarbazide 
• 1428787-56-7 (E)-N¹-(3-fluoro-4-(6-methoxy-7-(3-(4-methylpiperidin-1-yl)propoxy)quinolin-4-yloxy)phenyl)-N⁴-(4-fluorobenzylidene)semicarbazide 
• 1449763-27-2 (E)-N¹-(3-fluoro-4-(6-methoxy-7-(3-(4-methylpiperidin-1-yl)propoxy)quinolin-4-yloxy)phenyl)-N⁴-(4-chlorobenzylidene)semicarbazide 
• 1428787-47-6 (E)-N¹-(3-fluoro-4-(6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinolin-4-yloxy)phenyl)-N⁴-(benzylidene)semicarbazide 
• 1449763-28-3 (E)-N¹-(3-fluoro-4-(6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinolin-4-yloxy)phenyl)-N⁴-(4-fluorobenzylidene)semicarbazide 
• 1449763-29-4 (E)-N¹-(3-fluoro-4-(6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinolin-4-yloxy)phenyl)-N⁴-(4-chlorobenzylidene)semicarbazide 
• 1449763-03-4 (E)-N¹-(3-fluoro-4-(6-methoxy-7-(3-(piperidin-1-yl)propoxy)quinolin-4-yloxy)phenyl)-N⁴-(3,4-difluorobenzylidene)semicarbazide 
• 1449763-04-5 (E)-N¹-(3-fluoro-4-(6-methoxy-7-(3-(piperidin-1-yl)propoxy)quinolin-4-yloxy)phenyl)-N⁴-(2-fluorobenzylidene)semicarbazide 
• 1449763-05-6 (E)-N¹-(3-fluoro-4-(6-methoxy-7-(3-(piperidin-1-yl)propoxy)quinolin-4-yloxy)phenyl)-N⁴-(2,4-difluorobenzylidene)semicarbazide 
• 1449763-06-7 (E)-N¹-(3-fluoro-4-(6-methoxy-7-(3-(4-methylpiperidin-1-yl)propoxy)quinolin-4-yloxy)phenyl)-N⁴-(2-fluorobenzylidene)semicarbazide 
• 1428787-71-6 (E)-N⁴-(3-fluoro-4-(6-methoxy-7-(3-(4-methylpiperidin-1-yl)propoxy)quinoline-4-yloxy)phenyl)-N¹-(2,4-difluorobenzylidene)semicarbazide 
• 1449763-07-8 (E)-N¹-(3-fluoro-4-(6-methoxy-7-(3-(piperidin-1-yl)propoxy)quinolin-4-yloxy)phenyl)-N⁴-(2-trifluoromethylbenzylidene)semicarbazide 

Relevant articles and documents

Compound and application thereof in preparation of drugs for treating diseases caused by high expression of Flt3/c-Met kinase

The invention belongs to the technical field of chemical drug synthesis, and provides a compound and application thereof in preparation of drugs for treating diseases caused by high expression of Flt3/cMet kinase. The compound provided by the invention is prepared by amidation reaction of an intermediate A and an intermediate B. The compound provided by the invention has a strong effect of inhibiting Flt3/cMet kinase. The invention also discloses application of the compound and salt, solvate or prodrug thereof, or application of a pharmaceutical composition composed of one of the compound, salt, hydrate, solvate and prodrug thereof and an excipient in preparation of drugs for treating diseases caused by abnormal high expression of Flt3/cMet kinase, and application in drugs for treating and/or preventing proliferative diseases or cancers.

Novel substituted pyrazolo [1, 5-a] pyrimidine compound and preparation method and application thereof

The invention provides a novel substituted pyrazolo [1, 5-a]pyrimidine compound and a preparation method and application thereof, and particularly relates to a pyrazolo [1, 5-a]pyrimidine-containing quinoline derivative shown as a general formula (I) and pharmaceutically acceptable salts thereof, and substituent groups X, Ar and A have meanings given in the specification. The invention also relates to a compound represented by the general formula (I), wherein the compound has a strong c-Met kinase inhibition effect. The invention also relates to application of the compound and the pharmaceutically acceptable salt thereof in preparation of drugs for treating and/or preventing diseases caused by abnormal high expression of c-Met kinase, especially application in preparation of drugs for treating and/or preventing cancers.

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