1450-10-8

Basic information

• Product Name: 1-Propanone, 1-(4-bromophenyl)-2-(triphenylphosphoranylidene)-
• CAS NO: 1450-10-8
• Molecular Formula: C27H22BrOP
• Molecular Weight: 473.349
• Mol File: 1450-10-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1-Propanone, 1-(4-bromophenyl)-2-(triphenylphosphoranylidene)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Propanone, 1-(4-bromophenyl)-2-(triphenylphosphoranylidene)-(1450-10-8)
• EPA Substance Registry System: 1-Propanone, 1-(4-bromophenyl)-2-(triphenylphosphoranylidene)-(1450-10-8)

Safety Data

• Hazardous Substances Data: 1450-10-8(Hazardous Substances Data)

Usage

Appearance

Yellow liquid

Odor

Strong, sweet

Use

Organic synthesis reagent for introducing α-bromo ketone functionality, intermediate in production of pharmaceuticals and fine chemicals

Safety precautions

Causes skin, eye, and respiratory irritation, should be handled with care and in accordance with proper safety procedures.

Upstream product

• 1530-32-1 ethyltriphenylphosphonium bromide 
• 586-75-4 4-chlorobenzoyl chloride 
• 603-35-0 triphenylphosphine 
• 896-33-3 ethyltriphenylphosphonium chloride 

Downstream Products

• 791-28-6 Triphenylphosphine oxide 
• 42071-66-9 1-(4-bromophenyl)-2-methylprop-2-en-1-one 
• 10557-20-7 1-(4-bromophenyl)-1,2-propanedione 

Relevant articles and documents

Transition-Metal-Free Reductive Deoxygenative Olefination with CO2

A new transition-metal-free reductive deoxygenative olefination of phosphorus ylides with CO2, an abundant and sustainable C1 chemical feedstock, is described. This catalytic CO2 fixation afforded β-unsubstituted acrylates and vinyl ketones in good yields with broad scope and good functional group tolerance under mild reaction conditions. Cost-effective and easily handled polymethylhydrosiloxane was used as a reductant. Bis(silyl)acetal was proved to be the key intermediate in this reductive functionalization of CO2.

CONVENIENT PREPARATION OF UNSYMMETRICALLY SUBSTITUTED BENZILS BY PERMANGANATE OXIDATION OF β-OXO PHOSPHORUS YLIDES

Oxidative cleavage of a range of ylides 4 with R1 and/or R2 being aromatic groups, using KMnO4 in a two-phase system, affords unsymmetrical benzils and 1-arylpropane-1,2-diones 5 in moderate to good yield, and the ylide formation and oxidation can be combined in a convenient one-pot method.Key words: Phosphorus ylides, oxidation, 1,2-diketones, benzils, permanganate, oxoalkylidenetriphenylphosphoranes.