145122-34-5

Basic information

• Product Name: (10bS)-6,10b-dihydro-8,9-dimethoxy-10b-methyl-2-<(R)-1-phenylethyl>-5H-imidazo<4,3-a>isoquinoline-1(2H),3(4H)-dione
• Synonyms: (10bS)-6,10b-dihydro-8,9-dimethoxy-10b-methyl-2-<(R)-1-phenylethyl>-5H-imidazo<4,3-a>isoquinoline-1(2H),3(4H)-dione
• CAS NO: 145122-34-5
• Molecular Weight: 380.444
• Mol File: 145122-34-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (10bS)-6,10b-dihydro-8,9-dimethoxy-10b-methyl-2-<(R)-1-phenylethyl>-5H-imidazo<4,3-a>isoquinoline-1(2H),3(4H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: (10bS)-6,10b-dihydro-8,9-dimethoxy-10b-methyl-2-<(R)-1-phenylethyl>-5H-imidazo<4,3-a>isoquinoline-1(2H),3(4H)-dione(145122-34-5)
• EPA Substance Registry System: (10bS)-6,10b-dihydro-8,9-dimethoxy-10b-methyl-2-<(R)-1-phenylethyl>-5H-imidazo<4,3-a>isoquinoline-1(2H),3(4H)-dione(145122-34-5)

Safety Data

• Hazardous Substances Data: 145122-34-5(Hazardous Substances Data)

Upstream product

• 645-33-0 3-hydroxy-4-methoxy-β-phenethylamine hydrochloride 
• 110691-59-3 Methyl(+/-)-Salsoline-1-methylcarboxylate 
• 88598-26-9 salsoline-1-carboxylic acid 
• 186581-53-3 diazomethane 
• 110691-60-6 (1S)-1,2,3,4-tetrahydro-6-hydroxy-7-methoxy-1-methoxycarbonyl-1-methyl-2-<<(R)-1-phenylethyl>carbamoyl>isoquinoline 

Relevant articles and documents

Enantioselective synthesis of 1-substituted tetrahydroisoquinoline-1-carboxylic acids

The 3,4-dihydroisoquinolinium salt 1 and its enantiomer have been converted readily and stereoselectively into (+)- and (-)-1,2,3,4-tetrahydro-6,7-dimethoxy-1-methylisoquinoline-1-carboxylic acids.The synthetic route described should be applicable to the enantioselective synthesis of a variety of 1-alkyl- or 1-aryl-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acids.The absolute configuration of the amino acid hydrochloride 11 was established to be as depicted in scheme 2.