1452154-28-7

Basic information

• Product Name: Fmoc-Phe-O-azaPhe-Val-O^tBu
• Synonyms: Fmoc-Phe-O-azaPhe-Val-O^tBu
• CAS NO: 1452154-28-7
• Molecular Weight: 691.824
• Mol File: 1452154-28-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Fmoc-Phe-O-azaPhe-Val-O^tBu(CAS DataBase Reference)
• NIST Chemistry Reference: Fmoc-Phe-O-azaPhe-Val-O^tBu(1452154-28-7)
• EPA Substance Registry System: Fmoc-Phe-O-azaPhe-Val-O^tBu(1452154-28-7)

Safety Data

• Hazardous Substances Data: 1452154-28-7(Hazardous Substances Data)

Upstream product

• 100-52-7 benzaldehyde 
• 622-30-0 N-benzyl hydroxylalmine 
• 932-90-1 Benzaldoxime 
• 860800-19-7 9H-fluoren-9-ylmethyl N-[(1S)-1-benzyl-2-benzotriazol-1-yl-2-oxoethyl]carbamate 
• 1452153-84-2 HO-azaPhe-Val-O^tBu 
• 13518-40-6 L-valine tert-butylester hydrochloride 
• 1429433-67-9 (S)-tert-butyl 2-(1H-imidazole-1-carboxamido)-3-methylbutanoate 

Relevant articles and documents

Oxyazapeptides: Synthesis, structure determination, and conformational analysis

Herein we report the synthesis, X-ray structure determination, and conformational analysis of a novel class of heteroatom-modified peptidomimetics, which we shall call "oxyazapeptides". Substituting the typical native N-Cα bond with an O-Nα bond creates a completely new, previously unknown family of peptidomimetics, which are hydrolytically stable and display very interesting conformational behavior. Force field calculations revealed that the barrier to rotation around the O-Nα bond in oxyazapeptides is five times lower than that around the N-Nα bond in azapeptides. Also, conformational analysis supported by X-ray suggests that the oxyaza moiety can effectively induce β-turns, which can make the newly discovered oxyazapeptide scaffold a useful tool for drug discovery and for design of biologics.