860800-19-7

Basic information

• Product Name: 9H-fluoren-9-ylmethyl N-[(1S)-1-benzyl-2-benzotriazol-1-yl-2-oxoethyl]carbamate
• Synonyms: 9H-fluoren-9-ylmethyl N-[(1S)-1-benzyl-2-benzotriazol-1-yl-2-oxoethyl]carbamate
• CAS NO: 860800-19-7
• Molecular Weight: 488.546
• Mol File: 860800-19-7.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 9H-fluoren-9-ylmethyl N-[(1S)-1-benzyl-2-benzotriazol-1-yl-2-oxoethyl]carbamate(CAS DataBase Reference)
• NIST Chemistry Reference: 9H-fluoren-9-ylmethyl N-[(1S)-1-benzyl-2-benzotriazol-1-yl-2-oxoethyl]carbamate(860800-19-7)
• EPA Substance Registry System: 9H-fluoren-9-ylmethyl N-[(1S)-1-benzyl-2-benzotriazol-1-yl-2-oxoethyl]carbamate(860800-19-7)

Safety Data

• Hazardous Substances Data: 860800-19-7(Hazardous Substances Data)

Upstream product

• 95-14-7 1,2,3-Benzotriazole 
• 35661-40-6 N-Fmoc L-Phe 
• 103321-57-9 2S-flouren-9-ylmethoxycarbonylamino-3-phenylpropionyl chloride 

Downstream Products

• 1101836-40-1 H-L-Trp-L-Lys(Nε-Cc)-L-Met-L-Phe-NH2 
• 1101836-39-8 H-L-Pro-L-Phe-L-Lys(Nε-Cc)-NH2 
• 189455-66-1 Fmoc-Phe-Ala-OH 
• 1232149-65-3 Z-L-Thr-L-Cys(S-Fmoc-L-Phe)-OH 
• 1232149-60-8 Fmoc-L-Phe-S-L-Cys(NH₃Cl)-OH 
• 1260405-51-3 Fmoc-L-Phe-L-Cys(Fmoc-L-Phe)-OH 
• 1260405-52-4 Z-L-Ser-L-Cys(Fmoc-L-Phe)-OH 
• 1452154-28-7 Fmoc-Phe-O-azaPhe-Val-O^tBu 
• 1574526-74-1 Fmoc-L-Phe-Tau-OH 
• 1418181-50-6 (S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-phenylpropanethioic S-acid 

Relevant articles and documents

A simple and versatile method to synthesize N-acyl-benzotriazoles

An efficient method for the synthesis of N-acyl-benzotriazoles from a wide variety of protected amino acids, as well as from compounds frequently used in drug discovery such as biotin and N-Fmoc polyethylene glycol, has been developed. The reaction of car

Photoredox Alkenylation of Carboxylic Acids and Peptides: Synthesis of Covalent Enzyme Inhibitors

The synthesis of vinyl sulfones and (α,β-unsaturated) nitriles from carboxylic acids was realized through oxidative decarboxylation with 1,4-dicyanoanthracene as an organic photoredox catalyst. Various types of C-radicals are generated and used to construct three different classes of potential covalent protease inhibitors. The procedure is functional group tolerant and applicable to natural products and druglike scaffolds. It may serve for the rapid construction of screening candidates as demonstrated by a three-step synthesis of the known protease inhibitor K11777.

Benzotriazole-assisted solid-phase assembly of Leu-Enkephalin, amyloid β segment 34-42, and other "difficult" peptide sequences

Microwave-assisted solid-phase syntheses of six "difficult" peptides, H-VVSVV-NH2 (3), H-VVVSVV-NH2(4), H-VIVIG-OH (5), H-TVTVTV-NH2 (6), H-VKDGYI-NH2 (7), and H-VKDVYI-NH2 (8), were achieved utilizing N-(Fmoc-α-aminoacyl) benzotriazoles. Extension to the syntheses of Leu-enkephalin (9) and amyloid-β (34-42) (10) demonstrates that this strategy comprises an efficient route to new and known "difficult" peptides.