1452588-95-2

Basic information

• Product Name: methyl 2-isocyano-2-(4-bromophenyl)acetate
• Synonyms: methyl 2-isocyano-2-(4-bromophenyl)acetate
• CAS NO: 1452588-95-2
• Molecular Weight: 254.083
• Mol File: 1452588-95-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: methyl 2-isocyano-2-(4-bromophenyl)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2-isocyano-2-(4-bromophenyl)acetate(1452588-95-2)
• EPA Substance Registry System: methyl 2-isocyano-2-(4-bromophenyl)acetate(1452588-95-2)

Safety Data

• Hazardous Substances Data: 1452588-95-2(Hazardous Substances Data)

Upstream product

• 616-38-6 carbonic acid dimethyl ester 
• 3959-07-7 4-Bromobenzylamine 
• 933451-81-1 N-(4-bromolbenzyl)formamide 
• 42718-20-7 methyl 2-amino-2-(4-bromophenyl)acetate hydrochloride 
• 119397-06-7 2-amino-2-(4-bromophenyl)acetic acid 

Relevant articles and documents

Triple role of phenylselenonyl group enabled a one-pot synthesis of 1,3-oxazinan-2-ones from α-isocyanoacetates, phenyl vinyl selenones, and water

Reaction of α-substituted α-isocyanoacetates with phenyl vinyl selenones in the presence of a catalytic amount of base (DBU or Et3N, 0.05-0.1 equiv) followed by addition of p-toluenesulfonic acid (PTSA, 0.1-0.2 equiv) afforded 4,4,5-trisubstituted 1,3-oxazinan-2-ones in good to excellent yields. Enantiomerically enriched heterocycles can also be prepared using a Cinchona alkaloid-derived bifunctional organocatalyst for the Michael addition step. The phenylselenonyl group served as an activator for the Michael addition, a leaving group and a latent oxidant in this integrated reaction sequence.