42718-20-7

Basic information

• Product Name: METHYL 2-AMINO-2-(4-BROMOPHENYL)ACETATE HYDROCHLORIDE
• Synonyms: METHYL 2-AMINO-2-(4-BROMOPHENYL)ACETATE HYDROCHLORIDE;Methyl a-amino-4-bromobenzeneacetate HCl;methyl amino(4-bromophenyl)acetate hydrochloride;RS-4-Bromophenylglycine methyl ester hydrochloride
• CAS NO: 42718-20-7
• Molecular Formula: C₉H₁₀BrNO₂*ClH
• Molecular Weight: 280.55
• Mol File: 42718-20-7.mol
• Article Data: 4

Chemical Properties

• Melting Point: 205-208°C
• Appearance: /
• CAS DataBase Reference: METHYL 2-AMINO-2-(4-BROMOPHENYL)ACETATE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 2-AMINO-2-(4-BROMOPHENYL)ACETATE HYDROCHLORIDE(42718-20-7)
• EPA Substance Registry System: METHYL 2-AMINO-2-(4-BROMOPHENYL)ACETATE HYDROCHLORIDE(42718-20-7)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 42718-20-7(Hazardous Substances Data)

Usage

General Description

Methyl 2-amino-2-(4-bromophenyl)acetate hydrochloride is a chemical compound that belongs to the class of organic compounds known as phenylacetamides. It is a derivative of acetate and contains a bromo-substituted phenyl group attached to the amino group. METHYL 2-AMINO-2-(4-BROMOPHENYL)ACETATE HYDROCHLORIDE is typically used in the synthesis of pharmaceuticals and research chemicals. It has the potential to exhibit biological activity and may have applications in medicinal chemistry and drug development. The hydrochloride salt form of this compound is commonly used for ease of handling, storage, and dosing in laboratory settings. Overall, methyl 2-amino-2-(4-bromophenyl)acetate hydrochloride is an important chemical intermediate with potential uses in the pharmaceutical and research industries.

Upstream product

• 67-56-1 methanol 
• 119397-06-7 2-amino-2-(4-bromophenyl)acetic acid 
• 1122-91-4 4-bromo-benzaldehyde 

Downstream Products

• 1049837-69-5 methyl 2-(4-bromophenyl)-2-(2,3,4,5,6-pentafluorophenylsulfonamido)acetate 
• 1443792-42-4 methyl 2-(4-bromophenyl)-2-(5-(tert-butyl)thiophene-2-carboxamido)acetate 
• 1452588-95-2 methyl 2-isocyano-2-(4-bromophenyl)acetate 

Relevant articles and documents

Synthesis of 3-Hydroxymethyl Isoindolinones via Cobalt-Catalyzed C(sp2)-H Carbonylation of Phenylglycinol Derivatives

An efficient method for the synthesis of 3-hydroxymethyl isoindolinones via cobalt-catalyzed C(sp2)-H carbonylation of phenylglycinol derivatives using picolinamide as a traceless directing group is demonstrated. The reaction proceeds in the presence of a commercially available cobalt(II) tetramethylheptanedionate catalyst and employs DIAD as a "CO" surrogate. This synthetic route offers a broad substrate scope, excellent regioselectivity, and full preservation of the original stereochemistry. Besides, the developed method provides a pathway for accessing valuable enantiopure 3-substituted isoindolinone derivatives.

Triple role of phenylselenonyl group enabled a one-pot synthesis of 1,3-oxazinan-2-ones from α-isocyanoacetates, phenyl vinyl selenones, and water

Reaction of α-substituted α-isocyanoacetates with phenyl vinyl selenones in the presence of a catalytic amount of base (DBU or Et3N, 0.05-0.1 equiv) followed by addition of p-toluenesulfonic acid (PTSA, 0.1-0.2 equiv) afforded 4,4,5-trisubstituted 1,3-oxazinan-2-ones in good to excellent yields. Enantiomerically enriched heterocycles can also be prepared using a Cinchona alkaloid-derived bifunctional organocatalyst for the Michael addition step. The phenylselenonyl group served as an activator for the Michael addition, a leaving group and a latent oxidant in this integrated reaction sequence.