1452784-61-0

Basic information

• Product Name: (2S)-2-(benzoylamino)-3-methyl-N'-(2-chlorobenzylidene)butanohydrazide
• CAS NO: 1452784-61-0
• Molecular Weight: 357.84
• Mol File: 1452784-61-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2S)-2-(benzoylamino)-3-methyl-N'-(2-chlorobenzylidene)butanohydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: (2S)-2-(benzoylamino)-3-methyl-N'-(2-chlorobenzylidene)butanohydrazide(1452784-61-0)
• EPA Substance Registry System: (2S)-2-(benzoylamino)-3-methyl-N'-(2-chlorobenzylidene)butanohydrazide(1452784-61-0)

Safety Data

• Hazardous Substances Data: 1452784-61-0(Hazardous Substances Data)

Upstream product

• 1492-13-3 N-benzoyl-L-valine methyl ester 
• 2901-80-6 N-benzoyl-L-valine 
• 78867-91-1 (2S)-2-(benzoylamino)-3-methylbutyric acid hydrazide 
• 89-98-5 2-chloro-benzaldehyde 
• 72-18-4 L-valine 
• 98-88-4 benzoyl chloride 

Relevant articles and documents

Some hydrazones of 2-aroylamino-3-methylbutanohydrazide: Synthesis, molecular modeling studies, and identification as stereoselective inhibitors of HIV-1

In accordance with our antiviral drug development attempt, acylhydrazone derivatives bearing amino acid side chains were synthesized for the evaluation of their antiviral activity against various types of viruses. Among these compounds, 8S, 11S, and 12S showed anti-HIV-1 activity with a 50% inhibitory concentration (IC50) = 123.8 μM (selectivity index, SI > 3), IC50 = 12.1 μM (SI > 29), IC50 = 17.4 μM (SI > 19), respectively. Enantiomers 8 R, 11R, and 12R were inactive against the HIV-1 strain IIIB. Hydrazones 8S, 11S, and 12 S which were active against HIV-1 wild type showed no inhibition against a double mutant NNRTI-resistant strain (K103N;Y181C). Molecular docking calculations of R- and S-enantiomers of 8, 11, and 12 were performed using the hydrazone-bound novel site of HIV-1 RT. Copyright