1453851-69-8 Usage
Description
(S)-1-(2-(tert-butyldimethylsilyloxy)-1-(4-chloro-3-fluorophenyl)ethyl)-4-(2-(methylsulfonyl)pyrimidin-4-yl)pyridin-2(1H)-one is a complex organic molecule with a pyridin-2(1H)-one core, featuring a tert-butyldimethylsilyloxy group, a 4-chloro-3-fluorophenyl group, and a methylsulfonylpyrimidin-4-yl group as substituents. These structural elements confer unique chemical properties to the compound, making it a potential candidate for various applications in pharmaceutical research and other chemical fields.
Uses
Used in Pharmaceutical Research:
(S)-1-(2-(tert-butyldimethylsilyloxy)-1-(4-chloro-3-fluorophenyl)ethyl)-4-(2-(methylsulfonyl)pyrimidin-4-yl)pyridin-2(1H)-one is used as a research compound for exploring its potential therapeutic applications. (S)-1-(2-(tertbutyldimethylsilyloxy)-1-(4-chloro-3-fluorophenyl)ethyl)-4-(2-(methylsulfonyl)pyrimidin-4yl)pyridin-2(1H)-one's unique structure may offer novel interactions with biological targets, potentially leading to the development of new drugs for various diseases.
Used in Chemical Synthesis:
In the chemical industry, (S)-1-(2-(tert-butyldimethylsilyloxy)-1-(4-chloro-3-fluorophenyl)ethyl)-4-(2-(methylsulfonyl)pyrimidin-4-yl)pyridin-2(1H)-one can be used as a starting material or intermediate in the synthesis of other complex molecules. Its versatile structure allows for further functionalization and modification, enabling the creation of a wide range of chemical products.
Used in Material Science:
(S)-1-(2-(tertbutyldimethylsilyloxy)-1-(4-chloro-3-fluorophenyl)ethyl)-4-(2-(methylsulfonyl)pyrimidin-4yl)pyridin-2(1H)-one's unique chemical properties may also find applications in material science, where it could be utilized in the development of new materials with specific properties, such as improved stability, reactivity, or selectivity in various chemical processes.
Used in Analytical Chemistry:
(S)-1-(2-(tert-butyldimethylsilyloxy)-1-(4-chloro-3-fluorophenyl)ethyl)-4-(2-(methylsulfonyl)pyrimidin-4-yl)pyridin-2(1H)-one can be employed as a reference compound or standard in analytical chemistry. Its distinct structure and properties make it suitable for calibrating instruments, validating analytical methods, or studying the behavior of similar compounds under various conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 1453851-69-8 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,5,3,8,5 and 1 respectively; the second part has 2 digits, 6 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1453851-69:
(9*1)+(8*4)+(7*5)+(6*3)+(5*8)+(4*5)+(3*1)+(2*6)+(1*9)=178
178 % 10 = 8
So 1453851-69-8 is a valid CAS Registry Number.
1453851-69-8Relevant articles and documents
PROCESS FOR THE MANUFACTURING OF MEDICAMENTS
-
, (2017/02/24)
The present invention provides a process for the manufacture of a compound of formula VIIIa and salts forms of VIIIa where Rc is an aryl sulfonic acid
Discovery of highly potent, selective, and efficacious small molecule inhibitors of ERK1/2
Ren, Li,Grina, Jonas,Moreno, David,Blake, James F.,Gaudino, John J.,Garrey, Rustam,Metcalf, Andrew T.,Burkard, Michael,Martinson, Matthew,Rasor, Kevin,Chen, Huifen,Dean, Brian,Gould, Stephen E.,Pacheco, Patricia,Shahidi-Latham, Sheerin,Yin, Jianping,West, Kristina,Wang, Weiru,Moffat, John G.,Schwarz, Jacob B.
, p. 1976 - 1991 (2015/04/27)
Using structure-based design, a novel series of pyridone ERK1/2 inhibitors was developed. Optimization led to the identification of (S)-14k, a potent, selective, and orally bioavailable agent that inhibited tumor growth in mouse xenograft models. On the basis of its in vivo efficacy and preliminary safety profiles, (S)-14k was selected for further preclinical evaluation.
SERINE/THREONINE KINASE INHIBITORS
-
, (2013/09/12)
Compounds of Formula I or a stereoisomer, tautomer, prodrug or pharmaceutically acceptable salt thereof are provided, which are useful for the treatment of hyperproliferative, pain and inflammatory diseases. Methods of using compounds of Formula I or a stereoisomer, tautomer, prodrug or pharmaceutically acceptable salt thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
