145438-95-5 Usage
Description
1H-Indole-2-carboxylic acid, octahydro-, [2R-(2-alpha-,3a-bta-,7a-alpha-)]-(9CI), also known as (2R,3aR,7aS)-Octahydro-1H-indole-2-carboxylic Acid, is an organic compound with a complex molecular structure. It is characterized by its indole-based core and carboxylic acid functional group, which contribute to its unique chemical properties and potential applications.
Uses
Used in Pharmaceutical Industry:
1H-Indole-2-carboxylic acid, octahydro-, [2R-(2-alpha-,3a-bta-,7a-alpha-)]-(9CI) is used as a reactant for the preparation of stereoisomers of perindopril and perindoprilate. These stereoisomers are important in the development of pharmaceuticals, particularly in the treatment of hypertension and heart-related conditions. The compound's unique structure allows for the creation of these stereoisomers, which can have different therapeutic effects and properties.
Check Digit Verification of cas no
The CAS Registry Mumber 145438-95-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,5,4,3 and 8 respectively; the second part has 2 digits, 9 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 145438-95:
(8*1)+(7*4)+(6*5)+(5*4)+(4*3)+(3*8)+(2*9)+(1*5)=145
145 % 10 = 5
So 145438-95-5 is a valid CAS Registry Number.
145438-95-5Relevant articles and documents
Efficient access to N-protected derivatives of (R,R,R)- and (S,S,S)-octahydroindole-2-carboxylic acid by HPLC resolution
Sayago, Francisco J.,Jimenez, Ana I.,Cativiela, Carlos
, p. 2358 - 2364 (2008/02/12)
The preparation of the proline analogue (2S,3aS,7aS)-octahydroindole-2-carboxylic acid (Oic) and its enantiomer, (2R,3aR,7aR)-Oic, is described. A racemic precursor has been synthesized in good yield and subjected to HPLC resolution on a chiral column. The high efficiency of both the synthetic and chromatographic procedures has allowed the isolation of multigram quantities of each amino acid in enantiomerically pure form and suitably protected for use in peptide synthesis.
DIASTEREOSELECTIVE SYNTHESIS OF BICYCLIC AMINO ACIDS VIA RING CONTRACTION OF α-CHLOROLACTAMS
Henning, R.,Urbach, H.
, p. 5339 - 5342 (2007/10/02)
Bicyclic lactams were converted to their α-chloro-derivatives and subjected to ring contraction under basic conditions to give bicyclic acids in diasteroselective fashion.
