1454848-70-4

Basic information

• Product Name: tert-butyl (5-cyano-1-methyl-1H-pyrazol-3-yl)methyl(methyl)carbamate
• Synonyms: tert-butyl (5-cyano-1-methyl-1H-pyrazol-3-yl)methyl(methyl)carbamate
• CAS NO: 1454848-70-4
• Molecular Formula: C12H18N4O2
• Molecular Weight: 250.29692
• Mol File: 1454848-70-4.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: tert-butyl (5-cyano-1-methyl-1H-pyrazol-3-yl)methyl(methyl)carbamate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl (5-cyano-1-methyl-1H-pyrazol-3-yl)methyl(methyl)carbamate(1454848-70-4)
• EPA Substance Registry System: tert-butyl (5-cyano-1-methyl-1H-pyrazol-3-yl)methyl(methyl)carbamate(1454848-70-4)

Safety Data

• Hazardous Substances Data: 1454848-70-4(Hazardous Substances Data)

Upstream product

• 1454848-24-8 ((4-bromo-5-cyano-1-methyl-1H-pyrazol-3-yl)methyl)(methyl)carbamic acid tert-butyl ester 
• 5744-40-1 ethyl 1,3-dimethylpyrazole-5-carboxylate 
• 532410-39-2 1-(tert-butoxycarbonyl(methyl)amino)propan-2-one 

Downstream Products

• 1454852-76-6 1-methyl-3-[(methylamino)methyl]-1H-pyrazole-5-carbonitrile 
• 1454846-35-5 (10R)-7-amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h][2,5,11]-benzoxadiazacyclotetradecine-3-carbonitrile 
• 1612891-02-7 2-{(1R)-1-[(2-aminopyridin-3-yl)oxy]ethyl}-N-[(5-cyano-1-methyl-1H-pyrazol-3-yl)methyl]-4-fluoro-N-methylbenzamide 
• 1612891-03-8 2-{(1R)-1-[(2-amino-5-bromopyridin-3-yl)oxy]ethyl}-N-[(5-cyano-1-methyl-1H-pyrazol-3-yl)methyl]-4-fluoro-N-methylbenzamide 
• 1612891-04-9 2-[(1R)-1-{[5-bromo-2-(diacetylamino)pyridin-3-yl]oxy}-ethyl]-N-[(5-cyano-1-methyl-1H-pyrazol-3-yl)methyl]-4-fluoro-N-methylbenzamide 

Relevant articles and documents

SOLID FORMS OF A MACROCYCLIC KINASE INHIBITOR

This invention relates to crystalline solvates of (10R)-7-amino-12-fluoro-2,10,16- trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h][2,5,11]benz- oxadiazacyclotetradecine-3-carbonitrile, useful in the treatment of abnormal cell growt

MACROCYCLIC DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES

The invention relates to compounds of formula (Φ) as further defined herein and to the pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising such compounds and salts, and to the uses thereof. The compounds and salts of the present invention inhibit anaplastic lymphoma kinase (ALK) and/or EML4-ALK and are useful for treating or ameliorating abnormal cell proliferative disorders, such as cancer.