1454852-76-6 Usage
Description
1H-Pyrazole-5-carbonitrile, 1-methyl-3-[(methylamino)methyl]-, also known as Methyl 1H-pyrazole-5-carbonitrile, is a chemical compound with the molecular formula C7H9N5. It is a 1H-pyrazole derivative featuring a carbonitrile functional group and a methylaminomethyl substituent. 1H-Pyrazole-5-carbonitrile, 1-methyl-3-[(methylamino)methyl]is of interest in the fields of medicinal chemistry and organic chemistry due to its unique structure and properties.
Uses
Used in Pharmaceutical Synthesis:
1H-Pyrazole-5-carbonitrile, 1-methyl-3-[(methylamino)methyl]is utilized as an intermediate in the synthesis of pharmaceuticals. Its unique structure allows it to be a key component in the development of new drugs, contributing to the advancement of medicinal chemistry.
Used in Agrochemical Production:
1H-Pyrazole-5-carbonitrile, 1-methyl-3-[(methylamino)methyl]also serves as an intermediate in the synthesis of agrochemicals, playing a crucial role in the development of crop protection products. Its application in this industry helps to enhance agricultural productivity and protect crops from pests and diseases.
Used as a Reagent in Organic Synthesis:
1H-Pyrazole-5-carbonitrile, 1-methyl-3-[(methylamino)methyl]can be employed as a reagent in organic synthesis, facilitating various chemical reactions and the creation of new organic compounds for research and development purposes.
Used in Chemical Research:
Due to its structure and properties, Methyl 1H-pyrazole-5-carbonitrile is considered valuable in chemical research. It can be used to study the properties of 1H-pyrazole derivatives and their potential applications in different fields, further expanding the understanding of organic chemistry.
Check Digit Verification of cas no
The CAS Registry Mumber 1454852-76-6 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,5,4,8,5 and 2 respectively; the second part has 2 digits, 7 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1454852-76:
(9*1)+(8*4)+(7*5)+(6*4)+(5*8)+(4*5)+(3*2)+(2*7)+(1*6)=186
186 % 10 = 6
So 1454852-76-6 is a valid CAS Registry Number.
1454852-76-6Relevant articles and documents
1-methyl-3-((methylamino)methyl)-1H-pyrazole-5-nitrile synthesis method
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, (2019/01/14)
The invention belongs to the technical field of medicine and relates to a 1-methyl-3-((methylamino)methyl)-1H-pyrazole-5-nitrile synthesis method. Diethyl oxalate and acetone are easily acquirable andused as starting materials to obtain 1-methyl-3-((methylamino)methyl)-1H-pyrazole-5-nitrile through 7-step reaction including condensation, cyclization, methylation, amidation, oxidation, brominationand amination. By adoption of the method, preparation of 1-methyl-3-((methylamino)methyl)-1H-pyrazole-5-nitrile which is a key intermediate of antitumor drug lorlatinib (PF-06463922) is realized, thetotal yield reaches 5.7% or above, and simplicity in operation, convenience in aftertreatment, short time consumption and low cost are realized while industrialization can be realized beneficially. The intermediate and 5-fluoro-3-methyl isobenzofuran-1(3H)-ketone are subjected to reaction steps including ammonolysis, substitution, coupling, chiral resolution and the like to finally synthesize lorlatinib, and a novel method is provided for synthesis of the antitumor drug lorlatinib.
