1455272-61-3

Basic information

• Product Name: 4-(4-methylthiophenyl)-5-(phenyl)-2-(methylthio)-thiazole
• CAS NO: 1455272-61-3
• Molecular Weight: 329.511
• Mol File: 1455272-61-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-(4-methylthiophenyl)-5-(phenyl)-2-(methylthio)-thiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-methylthiophenyl)-5-(phenyl)-2-(methylthio)-thiazole(1455272-61-3)
• EPA Substance Registry System: 4-(4-methylthiophenyl)-5-(phenyl)-2-(methylthio)-thiazole(1455272-61-3)

Safety Data

• Hazardous Substances Data: 1455272-61-3(Hazardous Substances Data)

Upstream product

• 16696-83-6 S-methyl dithiocarbamate 
• 103089-98-1 2-bromo-1-(4''-(methylsulfanyl)phenyl)-2-phenyl-1-ethanone 
• 73242-07-6 2-phenyl-4'-(methylthio)acetophenone 
• 100-68-5 methyl-phenyl-thioether 
• 103-82-2 phenylacetic acid 

Relevant articles and documents

Synthesis, cytotoxic evaluation, and molecular docking study of 4,5-diaryl-thiazole-2-thione analogs of combretastatin A-4 as microtubule-binding agents

A series of combretastatin A-4 analogs in which cis-olefinic bond replaced by thiazole ring were prepared by reaction of α-bromo-1,2-(p-substituted) diaryl-1-ethanones and dithiocarbamate derivatives. The cytotoxicity of these compounds was determined against three cancer cell lines (HT-29), (MCF-7), (AGS) as well as fibroblastic cell line (NIH-3T3) using MTT assay. Inhibition of tubulin polymerization for some potent compounds was evaluated. These biological studies proved that 6j and 6o were the most potent compounds in this series. Furthermore 2-(methylthio)-substituted compounds show moderate or no activity. Docking studies involving 6j and 6o demonstrated that this analogs could be successfully docked in the colchicine binding site of α,β-tubulin.