73242-07-6

Basic information

• Product Name: Ethanone, 1-[4-(methylthio)phenyl]-2-phenyl-
• CAS NO: 73242-07-6
• Molecular Formula: C15H14OS
• Molecular Weight: 242.342
• Mol File: 73242-07-6.mol
• Article Data: 32

Chemical Properties

• CAS DataBase Reference: Ethanone, 1-[4-(methylthio)phenyl]-2-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 1-[4-(methylthio)phenyl]-2-phenyl-(73242-07-6)
• EPA Substance Registry System: Ethanone, 1-[4-(methylthio)phenyl]-2-phenyl-(73242-07-6)

Safety Data

• Hazardous Substances Data: 73242-07-6(Hazardous Substances Data)

Upstream product

• 7446-70-0 aluminium trichloride 
• 100-68-5 methyl-phenyl-thioether 
• 103-80-0 phenylacetyl chloride 
• 103-82-2 phenylacetic acid 
• 1442-06-4 4-(methylthio)benzoyl chloride 
• 100-39-0 benzyl bromide 
• 62673-31-8 benzyl(bromo)zinc 
• 201230-82-2 carbon monoxide 
• 100-44-7 benzyl chloride 
• 4747-15-3 1-(2-methoxyvinyl)benzene 
• 100-52-7 benzaldehyde 
• 3446-89-7 4-(Methylthio)benzaldehyde 

Downstream Products

• 54551-91-6 1-(4-(methylsulfonyl) phenyl)-2-phenylethan-1-one 
• 301693-52-7 2,2-dimethyl-5-[4-(methylthio)phenyl]-4-phenyl-3(2H)-furanone 
• 1313411-35-6 C₁₇H₁₄N₄O₂S₃ 
• 1326723-19-6 2-(4-fluorophenyl)-4-(4-methylsulfonylphenyl)-5-phenyl-1H-imidazole 
• 1326723-20-9 2-(4-chlorophenyl)-4-(4-methylsulfonylphenyl)-5-phenyl-1H-imidazole 
• 1326723-21-0 2-(4-methylphenyl)-4-(4-methylsulfonylphenyl)-5-phenyl-1H-imidazole 
• 1326723-22-1 2-(4-methoxyphenyl)-4-(4-methylsulfonylphenyl)-5-phenyl-1H-imidazole 
• 1326723-23-2 2-(4-hydroxyphenyl)-4-(4-methylsulfonylphenyl)-5-phenyl-1H-imidazole 
• 1326723-24-3 2-(4-acetamidophenyl)-4-(4-methylsulfonylphenyl)-5-phenyl-1H-imidazole 
• 1455272-61-3 4-(4-methylthiophenyl)-5-(phenyl)-2-(methylthio)-thiazole 
• 1455272-64-6 4-(4-methylthiophenyl)-5-(phenyl)-2-(benzylthio)-thiazole 

Relevant articles and documents

Palladium-catalyzed synthesis of α-aryl acetophenones from styryl ethers and aryl diazonium saltsviaregioselective Heck arylation at room temperature

Preparation of α-aryl acetophenones from styryl ethers and aryldiazonium salts is described. The reaction is catalyzed by palladium acetate at room temperature in the absence of ligand and base. The developed method is highly attractive in terms of reaction conditions, substrate scope, functional group tolerance and yields. Synthetic applications of the present method are demonstrated by preparing α-aryl indoles and 3-aryl isocoumarin from styryl ethers.

Synthesis and antiseizure activity of (E)-1,2-diarylethylidenehydrazine carboximidamides against tonic-clonic seizures: an intracerebroventricular and electrophysiological study

A series of (E)-1,2-diarylethylidenehydrazine carboximidamides 2a–j were synthesized and characterized by NOESY experiment as anticonvulsant agents and their antiseizure activity was evaluated by intracerebroventricular administration of compounds. Most of the compounds had significant protection against tonic-clonic seizures and 2a was found to be as equipotent as carbamazepine in seizures control. In order to find their anticonvulsant mechanism of action, 2a was subjected to further electrophysiological studies using patch-clamp technique. The results confirmed that this compound is neither a voltage-gated sodium channel blocker nor a NMDA/AMPA antagonist. Although 2a did not show any direct GABA agonistic activity, it could decrease EPSP and increase IPSP frequency without any change in amplitude. Finally, the results indicated most likely a presynaptic GABA-mediated mechanism of 2a for its antiseizure activity such as inhibition of the GABA-T which was validated by molecular docking.

3D QSAR studies based in silico screening of 4,5,6-triphenyl-1,2,3,4- tetrahydropyrimidine analogs for anti-inflammatory activity

The 3D QSAR studies based on generation of common pharmacophore hypotheses (CPHs) were performed separately for the series of 1,2,3,4-tetrahydropyrimidin- 5-yl-acetic acid and 2-(4-sulfonylphenyl)pyrimidine analogs for their in-vivo anti-inflammatory acti