54551-91-6

Basic information

• Product Name: Ethanone, 1-[4-(methylsulfonyl)phenyl]-2-phenyl-
• CAS NO: 54551-91-6
• Molecular Formula: C15H14O3S
• Molecular Weight: 274.34
• Mol File: 54551-91-6.mol
• Article Data: 14

Chemical Properties

• CAS DataBase Reference: Ethanone, 1-[4-(methylsulfonyl)phenyl]-2-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 1-[4-(methylsulfonyl)phenyl]-2-phenyl-(54551-91-6)
• EPA Substance Registry System: Ethanone, 1-[4-(methylsulfonyl)phenyl]-2-phenyl-(54551-91-6)

Safety Data

• Hazardous Substances Data: 54551-91-6(Hazardous Substances Data)

Upstream product

• 103-82-2 phenylacetic acid 
• 103-80-0 phenylacetyl chloride 
• 100-68-5 methyl-phenyl-thioether 
• 3112-85-4 methylphenylsulfonate 
• 73242-07-6 2-phenyl-4'-(methylthio)acetophenone 

Downstream Products

• 1326723-23-2 2-(4-hydroxyphenyl)-4-(4-methylsulfonylphenyl)-5-phenyl-1H-imidazole 
• 1542256-72-3 6-(4-(methylsulfonyl)phenyl)-3-(methylthio)-5-phenyl-1,2,4-triazine 
• 1542256-67-6 C₁₆H₁₃N₃O₂S₂ 
• 1542256-62-1 C₁₅H₁₃NO₄S 
• 1326723-24-3 2-(4-acetamidophenyl)-4-(4-methylsulfonylphenyl)-5-phenyl-1H-imidazole 
• 1326723-22-1 2-(4-methoxyphenyl)-4-(4-methylsulfonylphenyl)-5-phenyl-1H-imidazole 
• 1326723-21-0 2-(4-methylphenyl)-4-(4-methylsulfonylphenyl)-5-phenyl-1H-imidazole 
• 1326723-20-9 2-(4-chlorophenyl)-4-(4-methylsulfonylphenyl)-5-phenyl-1H-imidazole 
• 1326723-19-6 2-(4-fluorophenyl)-4-(4-methylsulfonylphenyl)-5-phenyl-1H-imidazole 
• 1326723-18-5 2,5-diphenyl-4-(4-methylsulfonylphenyl)-1H-imidazole 
• 1246522-17-7 (Z)-3-(4-methoxyphenyl)-1-(4-(methylsulfonyl)phenyl)-2-phenylprop-2-en-1-one 
• 1246522-16-6 (E)-3-(4-methoxyphenyl)-1-(4-(methylsulfonyl)phenyl)-2-phenylprop-2-en-1-one 
• 1246522-18-8 (E)-3-(4-hydroxyphenyl)-1-(4-(methylsulfonyl)phenyl)-2-phenylprop-2-en-1-one 
• 1246522-11-1 (Z)-1-(4-(methylsulfonyl)phenyl)-2,3-diphenylprop-2-en-1-one 

Relevant articles and documents

3D QSAR studies based in silico screening of 4,5,6-triphenyl-1,2,3,4- tetrahydropyrimidine analogs for anti-inflammatory activity

The 3D QSAR studies based on generation of common pharmacophore hypotheses (CPHs) were performed separately for the series of 1,2,3,4-tetrahydropyrimidin- 5-yl-acetic acid and 2-(4-sulfonylphenyl)pyrimidine analogs for their in-vivo anti-inflammatory acti

Design, synthesis and in vitro study of 5,6-diaryl-1,2,4-triazine-3-ylthioacetate derivatives as COX-2 and β-amyloid aggregation inhibitors

In order to find novel cyclooxygenase (COX)-2 inhibitors for treating inflammatory-based diseases such as Alzheimer's disease (AD), an ethyl carboxylate side chain was added to 5-(4-chlorophenyl)-6-(4-(methylsulfonyl)phenyl)-3-(methylthio)-1,2,4-triazine

Structure-based design and synthesis of antiparasitic pyrrolopyrimidines targeting pteridine reductase 1

The treatment of Human African trypanosomiasis remains a major unmet health need in sub-Saharan Africa. Approaches involving new molecular targets are important; pteridine reductase 1 (PTR1), an enzyme that reduces dihydrobiopterin in Trypanosoma spp., has been identified as a candidate target, and it has been shown previously that substituted pyrrolo[2,3-d]pyrimidines are inhibitors of PTR1 from Trypanosoma brucei (J. Med. Chem. 2010, 53, 221-229). In this study, 61 new pyrrolo[2,3-d]pyrimidines have been prepared, designed with input from new crystal structures of 23 of these compounds complexed with PTR1, and evaluated in screens for enzyme inhibitory activity against PTR1 and in vitro antitrypanosomal activity. Eight compounds were sufficiently active in both screens to take forward to in vivo evaluation. Thus, although evidence for trypanocidal activity in a stage I disease model in mice was obtained, the compounds were too toxic to mice for further development.