1459775-45-1

Basic information

• Product Name: 3-(4-isopropylphenyl)quinolin-2(1H)-one
• Synonyms: 3-(4-isopropylphenyl)quinolin-2(1H)-one
• CAS NO: 1459775-45-1
• Molecular Weight: 263.339
• Mol File: 1459775-45-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 3-(4-isopropylphenyl)quinolin-2(1H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-isopropylphenyl)quinolin-2(1H)-one(1459775-45-1)
• EPA Substance Registry System: 3-(4-isopropylphenyl)quinolin-2(1H)-one(1459775-45-1)

Safety Data

• Hazardous Substances Data: 1459775-45-1(Hazardous Substances Data)

Upstream product

• 100-63-0 phenylhydrazine 
• 99986-31-9 1-(4-isopropyl-phenyl)-2-nitro-ethanol 
• 122-03-2 (4-isopropylbenzaldehyde) 
• 948-65-2 2-phenyl-indole 
• 42139-37-7 1-isopropyl-4-(2-nitrovinyl)benzene 
• 95-20-5 2-methyl-1H-indole 

Relevant articles and documents

Metal-free ring expansion of indoles with nitroalkenes: A simple, modular approach to 3-substituted 2-quinolones

3-Substituted 2-quinolones are obtained via a novel metal-free transannulation reaction of 2-nitroolefins with 2-substituted indoles in polyphosphoric acid. This acid-mediated cascade transformation operates via the ANRORC (Addition of Nucleophile, Ring Opening, and Ring Closure) mechanism and can be used in combination with the Fisher indole synthesis to offer a practical three-component hetero-annulation approach to 2-quinolones from arylhydrazines, 2-nitroalkenes, and acetophenone. An alternative entry to this chemistry employing the alkylation of electron-rich arenes and hetarenes with 1-(2-indolyl)-2-nitroalkene has also been demonstrated.

Metal-free transannulation reaction of indoles with nitrostyrenes: A simple practical synthesis of 3-substituted 2-quinolones

3-Substituted 2-quinolones are obtained via a novel, metal-free transannulation reaction of 2-substituted indoles with 2-nitroalkenes in polyphosphoric acid. The reaction can be used in conjunction with the Fisher indole synthesis offering a practical three-component heteroannulation methodology to produce 2-quinolones from arylhydrazines, 2-nitroalkenes and acetophenone.