99986-31-9

Basic information

• Product Name: 1-(4-isopropyl-phenyl)-2-nitro-ethanol
• Synonyms: 1-(4-isopropyl-phenyl)-2-nitro-ethanol
• CAS NO: 99986-31-9
• Molecular Weight: 209.245
• Mol File: 99986-31-9.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 1-(4-isopropyl-phenyl)-2-nitro-ethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-isopropyl-phenyl)-2-nitro-ethanol(99986-31-9)
• EPA Substance Registry System: 1-(4-isopropyl-phenyl)-2-nitro-ethanol(99986-31-9)

Safety Data

• Hazardous Substances Data: 99986-31-9(Hazardous Substances Data)

Upstream product

• 75-52-5 nitromethane 
• 122-03-2 (4-isopropylbenzaldehyde) 

Downstream Products

• 42139-37-7 1-isopropyl-4-(2-nitrovinyl)benzene 
• 1459775-45-1 3-(4-isopropylphenyl)quinolin-2(1H)-one 
• 1310683-57-8 C₁₁H₁₃NO₃ 

Relevant articles and documents

α-Nitro-α,β-Unsaturated Ketones: An Electrophilic Acyl Transfer Reagent in Catalytic Asymmetric Friedel-Crafts and Michael Reactions

Herein, we introduce α-nitro-α,β-unsaturated ketones as efficient electrophilic acyl transfer reagents, and they were employed in Friedel-Crafts as well as in Michael reactions. The desired acyl transfer products of these reactions were obtained in high yields with high to excellent enantioselectivities with t-leucine-derived squaramide catalyst under mild reaction conditions. Few applications including a synthesis of the isoxazoline motif have been demonstrated.

Organocatalytic asymmetric Michael/hemiacetalization/acyl transfer reaction of α-nitroketones with o-hydroxycinnamaldehydes: Synthesis of 2,4-disubstituted chromans

An organocatalytic asymmetric cascade Michael/hemiketalization/acyl transfer reaction between o-hydroxycinnamaldehydes and α-nitroketones is developed. Prolinol TMS ether catalyst in combination with benzoic acid was found to be the most effective for this reaction which proceeds through an equilibrium of lactols to provide a single diastereomer of enantiopure 2,4-disubstituted chromans.

Organocatalytic Asymmetric Michael/Hemiketalization/Retro-aldol Reaction of α-Nitroketones with Unsaturated Pyrazolones: Synthesis of 3-Acyloxy Pyrazoles

An organocatalytic asymmetric cascade Michael/hemiketalization/retro-aldol reaction between unsaturated pyrazolones and α-nitroketones is described. A bifunctional thiourea catalyst was found to be efficient for this reaction. With 10 mol % of catalyst, high yields as well as excellent enantioselectivities are attained for a variety of 3-acyloxy pyrazoles under mild reaction conditions.