146397-21-9Relevant articles and documents
Bioorthogonally Applicable Fluorogenic Cyanine-Tetrazines for No-Wash Super-Resolution Imaging
Knorr, Gergely,Kozma, Eszter,Schaart, Judith M.,Németh, Krisztina,T?r?k, Gy?rgy,Kele, Péter
, p. 1312 - 1318 (2018)
The synthesis, fluorogenic characterization, and labeling application of four tetrazine-quenched cyanine probes with emission maxima in the red-far red range is reported. Fluorescence of the cyanine-cores is quenched via through-bond-energy-transfer (TBET) exerted by a bioorthogonal tetrazine unit. Upon bioorthogonal labeling reaction with cyclooctyne tagged proteins, the quenching effect ceases, and thus the fluorescence reinstates, resulting in an increase in fluorescence intensity. As a rare example among indocyanines, one of our new probes was found suitable in STED-based super-resolution imaging. The applicability of this fluorogenic Tet-Cy3 probe was therefore further demonstrated in the bioorthogonal labeling of cytoskeletal protein, actin, with subsequent super-resolution microscopy (STED) imaging even under no-wash conditions.
NOVEL CYANINE COMPOUND FOR LABELING BIOMOLECULE AND PREPARATION METHOD THEREOF
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, (2018/04/18)
The present invention refers to biomolecule marker has a cyanine compound and number to the next formula 1 bath method are disclosed. [Formula 1] Another test, R1 , R2 , R3 , R4 , B, m and n each specification defines efined. (by machine translation)
Imaging agents useful for brain and prepration method thereof
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Paragraph 0103; 0202-0204, (2017/08/02)
The present invention relates to a fluorescent dye for brain imaging, which is represented by the following [Chemical Formula 1]. [Chemical Formula 1] In the [Chemical Formula 1], R_1, R_2, R_3, R_4, R_5, and n are as defined in the specification.(AA) Example 1(BB) Example 3(CC) Example 4(DD) Example 5COPYRIGHT KIPO 2017
