146452-39-3Relevant articles and documents
Stereoselective, biocatalytic reductions of α-chloro-β-keto esters
Kaluzna, Iwona A.,Feske, Brent D.,Wittayanan, Weerawut,Ghiviriga, Ion,Stewart, Jon D.
, p. 342 - 345 (2005)
(Chemical Equation Presented). Eighteen known and putative reductases from baker's yeast (Saccharomyces cerevisiae) were tested for the ability to reduce a series of α-chloro-β-keto esters. In nearly all cases, it was possible to produce at least two of t
Asymmetric reduction of 2-chloro-3-oxo esters by transfer hydrogenation
Bai, Jinjin,Miao, Shifeng,Wu, Yun,Zhang, Yawen
experimental part, p. 2476 - 2480 (2012/02/04)
Asymmetric reduction of 2-chloro-3-oxo esters was achieved by catalytic transfer hydrogenation using [RuCl2(p-cymene)](S,S)-TsDPEN as the chiral catalyst and HCOOH-Et3N as the hydrogen source. Moderate to good yields (up to 85%) and
Enantiodivergent, biocatalytic routes to both taxol side chain antipodes
Feske, Brent D.,Kaluzna, Iwona A.,Stewart, Jon D.
, p. 9654 - 9657 (2007/10/03)
Two enantiocomplementary bakers' yeast enzymes reduced an α-chloro-β-keto ester to yield precursors for both enantiomers of the N-benzoyl phenylisoserine Taxol side chain. After base-mediated ring closure of the chlorohydrin enantiomers, the epoxides were
