41381-97-9Relevant articles and documents
PHARMACEUTICAL COMPOUNDS
-
Page/Page column 62-63, (2021/02/26)
Benzodiazepine derivatives of formula (I): (I) wherein: each of R1 and R2 is independently H or halo; either (i) T is N, Z is C, ---a--- and ---c--- are bonds, and ---b--- and ---d--- are absent; or (ii) T is C, Z is N, ---b--- and ---d--- are bonds, and ---a--- and ---c--- are absent; each of R3 and R4 is independently halo, -OR6, -NR6R7, -COR8, -C(O)OR8, -CON(R8)2 or -R6; R5 is H or halo; each of R6 and R7 is independently H or a group selected from C1-C6 alkyl, C3-C10 cycloalkyl, C6-C10 aryl, 4- to 10-membered heterocyclyl and 4- to 10-membered heteroaryl, the group being unsubstituted or substituted; R8 is H or C1-C6 alkyl, each R8 being the same or different when two are present; n is 0 or 1; and one of V, W, X and Y is N or CH and the other three are CH; and the pharmaceutically acceptable salts thereof are inhibitors of RSV and can therefore be used to treat or prevent an RSV infection.
SAR Studies of the Leupyrrins: Design and Total Synthesis of Highly Potent Simplified Leupylogs
Wosniok, Paul R.,Knopf, Christopher,Dreisigacker, Sandra,Orozco-Rodriguez, J. Manuel,Hinkelmann, Bettina,Mueller, Peter P.,Br?nstrup, Mark,Menche, Dirk
supporting information, p. 15074 - 15078 (2020/10/19)
Leupyrrins are highly potent antifungal agents. A structure–activity-relationship study of natural and synthetic derivatives is reported which reveals important insights into the biological relevance of several structural subunits leading to the discovery
CALPAIN MODULATORS AND THERAPEUTIC USES THEREOF
-
Paragraph 0485, (2018/04/17)
Disclosed herein are small molecule calpain modulator compositions, pharmaceutical compositions, the use and preparation thereof.