146758-90-9

Basic information

• Product Name: Silane, 1-butynyldimethylphenyl-
• CAS NO: 146758-90-9
• Molecular Formula: C12H16Si
• Molecular Weight: 188.345
• Mol File: 146758-90-9.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Silane, 1-butynyldimethylphenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Silane, 1-butynyldimethylphenyl-(146758-90-9)
• EPA Substance Registry System: Silane, 1-butynyldimethylphenyl-(146758-90-9)

Safety Data

• Hazardous Substances Data: 146758-90-9(Hazardous Substances Data)

Upstream product

• 107-00-6 but-1-yne 
• 768-33-2 phenyldimethylsilyl chloride 
• 73383-24-1 1,1-dibromo-3-methylprop-1-ene 
• 3839-31-4 dimethyl(phenyl)silyllithium 
• 120627-94-3 1-(Dimethyl-phenyl-silanyl)-butan-1-one 

Downstream Products

• 215546-34-2 (E)-1-Cyclohexyl-4-(dimethyl-phenyl-silanyl)-pent-2-en-1-ol 
• 215546-03-5 Acetic acid (E)-1-cyclohexyl-4-(dimethyl-phenyl-silanyl)-pent-2-enyl ester 
• 215546-29-5 1-Cyclohexyl-4-(dimethyl-phenyl-silanyl)-pent-2-yn-1-ol 
• 132841-67-9 Toluene-4-sulfonic acid (1R,4R)-1-cyclohexyl-4-(dimethyl-phenyl-silanyl)-pentyl ester 
• 132841-67-9 Toluene-4-sulfonic acid (1S,4R)-1-cyclohexyl-4-(dimethyl-phenyl-silanyl)-pentyl ester 
• 132841-63-5 (Z)-(1S,4R)-1-Cyclohexyl-4-(dimethyl-phenyl-silanyl)-pent-2-en-1-ol 
• 132841-63-5 (Z)-(1R,4R)-1-Cyclohexyl-4-(dimethyl-phenyl-silanyl)-pent-2-en-1-ol 
• 679410-10-7 {Dimethyl-[(E)-1-methyl-4-(1-trimethylsilanyloxy-vinyloxy)-but-2-enyl]-silanyl}-benzene 
• 679409-96-2 {Dimethyl-[(Z)-1-methyl-4-(1-trimethylsilanyloxy-vinyloxy)-but-2-enyl]-silanyl}-benzene 
• 679409-99-5 (E)-4-dimethyl(phenyl)silylpent-2-enyl acetate 
• 679410-00-5 (Z)-4-dimethyl(phenyl)silylpent-2-enyl acetate 
• 677353-06-9 methyl 4-dimethyl(phenyl)silylpent-2-ynoate 
• 677353-07-0 (Z)-methyl 4-dimethyl(phenyl)silylpent-2-enoate 
• 679410-20-9 (E)-4-dimethyl(phenyl)silylpent-2-en-1-ol 

Relevant articles and documents

Catalytic carbometalation/cross-coupling sequence across alkynyl(2-pyridyl)silanes leading to a diversity-oriented synthesis of tamoxifen-type tetrasubstituted olefins

A general synthetic scheme for tamoxifen-type tetrasubstituted olefins based on the novel Cu-catalyzed carbomagnesation across alkynyl(2-pyridyl)silane has been developed. A wide array of electronically and structurally diverse tetrasubstituted olefins can be prepared in a regiocontrolled, stereo-controlled, and diversity-oriented manner. Noteworthy features are that (i) the three aryl groups, which are believed to be important (essential) for anti-estrogenic activity, can be varied at will because they all stem from readily available aryl iodides, and (ii) any stereo- and regioisomers can, in principle, be prepared by simply changing the order use of the aryl iodides in the sequence.

Diversity-Oriented Synthesis of Tamoxifen-type Tetrasubstituted Olefins

A general synthetic scheme for tamoxifen-type tetrasubstituted olefins based on the novel Cu-catalyzed carbomagnesation across alkynyl(2-pyridyl)silane has been developed. A wide array of electronically and structurally diverse tetrasubstituted olefins can be prepared in a regiocontrolled, stereocontrolled, and diversity-oriented manner. Noteworthy features are that (i) the three aryl groups, which are believed to be important (essential) for anti-estrogenic activity, can be varied at will because they all stem from readily available aryl iodides, and (ii) any stereo- and regioisomers can, in principle, be prepared by simply changing the applying order of aryl iodides into the sequence. Copyright

A synthesis of enantiomerically enriched propargyl silanes

Reduction of ethyl 3-methyl-, 3-isopropyl- and 3-n-pentyl-3-[dimethyl(phenyl)silyl]propanoates 4 with DIBAL to the aldehydes 5, enol trifluoromethanesulfonate (triflate) formation using trifluoromethanesulfonic (triflic) anhydride and 2,6-di-tert-butylpyridine, and elimination using LDA, gives the propargyl silanes 8. The esters 4 could also be prepared enantiomerically enriched (11), and the final products are the enantiomerically enriched propargyl (homochiral) silanes 14.