146798-12-1

Basic information

• Product Name: N-phenethyl-3-(3-methoxyphenyl)piperidine
• Synonyms: N-phenethyl-3-(3-methoxyphenyl)piperidine
• CAS NO: 146798-12-1
• Molecular Weight: 295.425
• Mol File: 146798-12-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-phenethyl-3-(3-methoxyphenyl)piperidine(CAS DataBase Reference)
• NIST Chemistry Reference: N-phenethyl-3-(3-methoxyphenyl)piperidine(146798-12-1)
• EPA Substance Registry System: N-phenethyl-3-(3-methoxyphenyl)piperidine(146798-12-1)

Safety Data

• Hazardous Substances Data: 146798-12-1(Hazardous Substances Data)

Upstream product

• 36282-40-3 (3-methoxyphenyl)magnesium bromide 
• 4373-67-5 3-(3-methoxyphenyl)pyridine 
• 626-55-1 3-Bromopyridine 
• 103-82-2 phenylacetic acid 
• 79601-21-1 3-(3-methoxyphenylpiperidine) 

Downstream Products

• 89874-95-3 3-((R)-1-Phenethyl-piperidin-3-yl)-phenol 
• 19725-24-7 3-(3-hydroxyphenyl)-N-phenethylpiperidine 

Relevant articles and documents

3-Phenylpiperidines. Central Dopamine-Autoreceptor Stimulating Activity

Thirty compounds related to the selective dopamine-autoreceptor agonist 3-(3-hydroxyphenyl)-N-n-propylpiperidine have been synthesized and tested for central dopamine-autoreceptor stimulating activity.The 3-(3-hydroxyphenyl)piperidine moiety seems indispensable for high potency and selectivity.Introduction of an additional hydroxyl group into the 4-position of the aromatic ring gives a compound with dopaminergic activity but lacking selectivity for autoreceptors. 3-(3-Hydroxyphenyl)-N-n-propylpyrrolidine, 3-(3-hydroxy)-N-n-propylperhydroazepine, and 3-(3-hydroxyphenyl)quinuclidine were all inactive.The most potent compounds were the N-isopropyl-, N-n-butyl-, N-n-pentyl-, and N-phenethyl-substituted 3-(3-hydroxyphenyl)piperidine derivatives.None of the compounds investigated seemed to have central noradrenaline- or serotonin-receptor stimulating activity.