79601-21-1

Basic information

• Product Name: 3-(3-METHOXYPHENYL)-PIPERIDINE
• Synonyms: 3-(3-Methoxyphenyl)piperidine
• CAS NO: 79601-21-1
• Molecular Formula: C₁₂H₁₇NO
• Molecular Weight: 191.28
• Mol File: 79601-21-1.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 303.682 °C at 760 mmHg
• Flash Point: 122.355 °C
• Appearance: /
• Density: 1.003 g/cm³
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.515
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• CAS DataBase Reference: 3-(3-METHOXYPHENYL)-PIPERIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(3-METHOXYPHENYL)-PIPERIDINE(79601-21-1)
• EPA Substance Registry System: 3-(3-METHOXYPHENYL)-PIPERIDINE(79601-21-1)

Safety Data

• Hazardous Substances Data: 79601-21-1(Hazardous Substances Data)

Usage

General Description

3-(3-Methoxyphenyl)-piperidine is a chemical compound that belongs to the piperidine class of organic compounds. It is a white to off-white crystalline powder that is primarily used as an intermediate in the synthesis of pharmaceutical drugs and other organic compounds. This chemical has been studied for its potential pharmacological properties, including its ability to act as a serotonin and norepinephrine reuptake inhibitor, which could make it useful in the development of medications for the treatment of depression and other mood disorders. Additionally, 3-(3-Methoxyphenyl)-piperidine has also been investigated for its potential analgesic properties, with some research suggesting it may be useful in the development of new pain-relief medications.

InChI:InChI=1/C12H17NO/c1-14-12-6-2-4-10(8-12)11-5-3-7-13-9-11/h2,4,6,8,11,13H,3,5,7,9H2,1H3

Upstream product

• 4373-67-5 3-(3-methoxyphenyl)pyridine 
• 906360-18-7 1-methanesulfonyl-3-(3-methoxy-phenyl)-piperidine 
• 906360-22-3 3-(3-methoxyphenyl)-1-p-toluenesulfonylpiperidine 
• 6859-99-0 3-hydroxypiperazine 
• 444606-08-0 1-(methylsulfonyl)piperidin-3-ol 
• 906360-16-5 1-mesyl piperidin-3-one 
• 220384-68-9 1-(p-toluenesulfonyl)-piperidin-3-ol 
• 220384-55-4 1-(p-toluenesulfonyl)-piperidin-3-one 
• 626-55-1 3-Bromopyridine 
• 36282-40-3 (3-methoxyphenyl)magnesium bromide 
• 69966-49-0 3-phenoxymethyl-pyridine 
• 850761-36-3 tert-butyl 3-iodo-1-piperidinecarboxylate 
• 71381-75-4 N-(tert-butyloxycarbonyl)nipecotic acid 
• 684215-27-8 bis-(3-methoxyphenyl)zinc 

Downstream Products

• 146798-12-1 N-phenethyl-3-(3-methoxyphenyl)piperidine 
• 79412-38-7 3-(piperidin-3-yl)phenol hydrobromide 
• 88784-37-6 (+)-(S)-3-(3-methoxyphenyl)piperidine 
• 103291-08-3 (3S)-(-)-3-(3-methoxyphenyl)piperidine 
• 138552-56-4 [3-(3-Methoxy-phenyl)-piperidin-1-yl]-phenyl-methanone 
• 79412-66-1 N-butyryl-3-(3-methoxyphenyl)piperidine 
• 79601-37-9 N-isopropyl-3-(3-methoxyphenyl)piperidine 
• 79601-38-0 1-(2,2-Dimethyl-propyl)-3-(3-methoxy-phenyl)-piperidine 
• 86562-23-4 (+/-)-3-(3-methoxyphenyl)-N-n-propylpiperidine 
• 75240-91-4 1-propyl-3-(3-hydroxyphenyl)piperidine 
• 89874-51-1 (+)-(S)-3-(3-methoxyphenyl)-1-propylpiperidine 
• 91110-04-2 (3S)-(-)-3-(3-methoxyphenyl)-1-propylpiperidine 
• 147161-65-7 (S)-N-propyl-3-(3-methoxy-4-aminophenyl)piperidine 
• 147161-64-6 (R)-N-propyl-3-(3-methoxy-4-aminophenyl)piperidine 

Relevant articles and documents

TRIAZACYCLODODECANSULFONAMIDE ("TCD")-BASED PROTEIN SECRETION INHIBITORS

Provided herein are triazacyclododecansulfonamide ("TCD")-based protein secretion inhibitors, such as inhibitors of Sec61, methods for their preparation, related pharmaceutical compositions, and methods for using the same. For example, provided herein are compounds of Formula (I) and pharmaceutically acceptable salts and compositions including the same. The compounds disclosed herein may be used, for example, in the treatment of diseases including inflammation and/or cancer.

Cobalt-Catalyzed Cross-Coupling of 3- and 4-Iodopiperidines with Grignard Reagents

A cobalt-catalyzed cross-coupling between 3- and 4-iodopiperidines and Grignard reagents is disclosed. The reaction is an efficient, cheap, chemoselective, and flexible way to functionalize piperidines. This coupling was used as the key step to realize a short synthesis of (±)-preclamol. Some mechanistic investigations were conducted that highlight the formation of radical intermediates. Scaffold synthesis: A cobalt-catalyzed cross-coupling between iodopiperidines and Grignard reagents is reported (see scheme; PG=protecting group). A large variety of 3- and 4-substituted piperidines were synthesized and the method was applied to a short synthesis of (±)-preclamol. This work constitutes one of the rare examples of cross-couplings involving 3-halogeno piperidines.

PHENYL SUBSTITUTED PIPERIDINE COMPOUNDS FOR USE AS PPAR ACTIVATORS

PPAR alpha activators, pharmaceutical compositions containing such compounds and the use of such compounds to elevate certain plasma lipid levels, including high density lipoprotein-cholesterol and to lower certain other plasma lipid levels, such as LDL-cholesterol and triglycerides and accordingly to treat diseases which are exacerbated by low levels of HDL cholesterol and/or high levels of LDL-cholesterol and triglycerides, such as atherosclerosis and cardiovascular diseases, in mammals, including humans.