88784-37-6Relevant articles and documents
TRIAZACYCLODODECANSULFONAMIDE ("TCD")-BASED PROTEIN SECRETION INHIBITORS
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, (2019/10/04)
Provided herein are triazacyclododecansulfonamide ("TCD")-based protein secretion inhibitors, such as inhibitors of Sec61, methods for their preparation, related pharmaceutical compositions, and methods for using the same. For example, provided herein are compounds of Formula (I) and pharmaceutically acceptable salts and compositions including the same. The compounds disclosed herein may be used, for example, in the treatment of diseases including inflammation and/or cancer.
Enantioselective synthesis of 2-substituted and 3-substituted piperidines through a bromoaminocyclization process
Zhou, Ling,Tay, Daniel Weiliang,Chen, Jie,Leung, Gulice Yiu Chung,Yeung, Ying-Yeung
, p. 4412 - 4414 (2013/05/22)
A catalytic enantioselective bromocyclization of olefinic amides using amino-thiocarbamates as the catalysts has been developed. The resulting enantioenriched 2-substituted 3-bromopiperidines can readily be transformed to 3-substituted piperidines through
N-OXIDE AND/OR DI-N-OXIDE DERIVATIVES OF DOPAMINE RECEPTOR STABILIZERS/MODULATORS DISPLAYING IMPROVED CARDIOVASCULAR SIDE-EFFECTS PROFILES
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Page/Page column 25, (2008/12/08)
The invention relates to N-oxide and/or di-N-oxide derivatives of dopamine receptor stabilizers/modulators having the general formula (1) or (2) and pharmaceutical preparations containing the said compounds. Further, the invention relates the use of the s