147118-27-2

Basic information

• Product Name: Ethyl 4-(4-Fluorophenyl)-6-isopropyl-2-methylthiopyrimidine-5-carboxylate
• Synonyms: Ethyl 4-(4-Fluorophenyl)-6-isopropyl-2-methylthiopyrimidine-5-carboxylate
• CAS NO: 147118-27-2
• Molecular Formula: C₁₇H₁₉FN₂O₂S
• Molecular Weight: 334.4083632
• Product Categories: Aromatics Compounds;Aromatics;Sulfur & Selenium Compounds;Bases & Related Reagents;Nucleotides;Aromatics, Nucleotides, Bases & Related Reagents, Sulfur & Selenium Compounds
• Mol File: 147118-27-2.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 483.6±45.0 °C(Predicted)
• Appearance: /
• Density: 1.23±0.1 g/cm3(Predicted)
• Solubility: Dichloromethane, Ethyl Acetate, Methanol
• PKA: -0.44±0.50(Predicted)
• CAS DataBase Reference: Ethyl 4-(4-Fluorophenyl)-6-isopropyl-2-methylthiopyrimidine-5-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl 4-(4-Fluorophenyl)-6-isopropyl-2-methylthiopyrimidine-5-carboxylate(147118-27-2)
• EPA Substance Registry System: Ethyl 4-(4-Fluorophenyl)-6-isopropyl-2-methylthiopyrimidine-5-carboxylate(147118-27-2)

Safety Data

• Hazardous Substances Data: 147118-27-2(Hazardous Substances Data)

Usage

Chemical Properties

Pale Yellow Oil

Uses

An intermediate of Rosuvastatin (R700500).

Upstream product

• 867-44-7 S-Methylisothiourea sulfate 
• 122930-45-4 (E)-2-<(4-fluorophenyl)methylene>-4-methyl-3-oxopentanoic acid ethyl ester 
• 75-91-2 tert.-butylhydroperoxide 
• 459-57-4 4-fluorobenzaldehyde 
• 7152-15-0 ethyl 4-methyl-3-oxo-pentanoate 
• 1619238-14-0 ethyl 4-(4-fluorophenyl)-2-(methylsulfanyl)-6-(propan-2-yl)-1,4-dihydropyrimidine-5-carboxylate 

Downstream Products

• 895129-11-0 4-(4'-fluorophenyl)-6-isopropyl-2-methylthio-5-hydroxymethyl-pyrimidine 
• 147118-28-3 ethyl 4-(4-fluorophenyl)-6-isopropyl-2-(methylsulfonyl)pyrimidine-5-carboxylate 
• 849470-61-7 4-(4-fluorophenyl)-6-isopropyl-2-(methylsulfonyl)pyrimidine-5-carbaldehyde 
• 849470-59-3 (4-(4-fluorophenyl)-6-isopropyl-2-(methylsulfonyl)pyrimidin-5-yl)methanol 
• 147118-32-9 5-ethoxycarbonyl-6-(4'-fluorophenyl)-4-isopropyl-2-(methylamino)pyrimidine 
• 147118-33-0 5-ethoxycarbonyl-6-(4'-fluorophenyl)-4-isopropyl-2-methoxypyrimidine 
• 147118-36-3 N-[4-(4-fluorophenyl)-5-(hydroxymethyl)-6-(propan-2-yl)pyrimidin-2-yl]-N-methylmethanesulfonamide 
• 147118-37-4 N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide 
• 147118-23-8 (E)-(3R,5S)-7-[4-(4-Fluoro-phenyl)-6-isopropyl-2-methylsulfanyl-pyrimidin-5-yl]-3,5-dihydroxy-hept-6-enoic acid methyl ester 
• 147118-25-0 (E)-(3R,5S)-7-[4-(4-Fluoro-phenyl)-6-isopropyl-2-methoxy-pyrimidin-5-yl]-3,5-dihydroxy-hept-6-enoic acid methyl ester 
• 147118-30-7 ethyl 2-(N-methyl-N-methanesulfonylamino)-4-(4-fluorophenyl)-6-isopropyl-pyrimidin-5-carboxylic acid 
• 147118-34-1 C₁₈H₂₃FN₄O₄S 
• 147118-24-9 (E)-(3R,5S)-7-[4-(4-Fluoro-phenyl)-6-isopropyl-2-methanesulfonyl-pyrimidin-5-yl]-3,5-dihydroxy-hept-6-enoic acid methyl ester 

Relevant articles and documents

Preparation of [6-isopropyl-4 - (4-fluoro phenyl) - 2-thio-5-yl] methyl ester

The invention relates to a preparation method of a pharmaceutical chemical intermediate and particularly relates to a preparation method of [6-isopropyl-4- (4-fluorophenyl)-2-thio-5-yl]formate. According to the method, p-fluorobenzaldehyde, isobutyryl ace

Oxidative dehydrogenation of dihydropyrimidinones and dihydropyrimidines

(Chemical Equation Presented) A mild, practical procedure for oxidative dehydrogenation with catalytic amounts of a Cu salt, K2CO 3, and tert-butylhydroperoxide (TBHP) as a terminal oxidant has been developed. This oxidation procedure is generally applicable to dihydropyrimidinones and most dihydropyrimidines.

PYRIMIDINE DERIVATIVES

The compounds of the present invention inhibit the HMG-CoA reductase, and subsequently suppress the biosynthesis of cholesterol. And they are useful in the treatment of hypercholesterolemia, hyperlipoproteinemia, and atherosclerosis