1472611-44-1

Basic information

• Product Name: 4-(2-aminoethoxy)-N2,N6-bis(4-(2-aminoethoxy)quinolin-2-yl)pyridine-2,6-dicarboxamide tris(trifluoroacetate)
• CAS NO: 1472611-44-1
• Molecular Weight: 938.718
• Mol File: 1472611-44-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-(2-aminoethoxy)-N2,N6-bis(4-(2-aminoethoxy)quinolin-2-yl)pyridine-2,6-dicarboxamide tris(trifluoroacetate)(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-aminoethoxy)-N2,N6-bis(4-(2-aminoethoxy)quinolin-2-yl)pyridine-2,6-dicarboxamide tris(trifluoroacetate)(1472611-44-1)
• EPA Substance Registry System: 4-(2-aminoethoxy)-N2,N6-bis(4-(2-aminoethoxy)quinolin-2-yl)pyridine-2,6-dicarboxamide tris(trifluoroacetate)(1472611-44-1)

Safety Data

• Hazardous Substances Data: 1472611-44-1(Hazardous Substances Data)

Usage

Uses

Pyridostatin Trifluoroacetate Salt is G4s stabilizer.

Upstream product

• 76-05-1 trifluoroacetic acid 
• 42712-64-1 2-amino-quinolin-4-ol 
• 1085412-34-5 dimethyl-4-(2-(tert-butoxycarbonylamino)ethoxy)-2,6-pyridinedicarboxylate 
• 1085412-36-7 4-(2-tert-butoxycarbonylamino-ethoxy)-quinolin-2-yl amine 
• 1085412-35-6 4-(2-(tert-butoxycarbonylamino)ethoxy)-2,6-pyridinedicarboxylic acid 

Relevant articles and documents

Pyridostatin analogues promote telomere dysfunction and long-term growth inhibition in human cancer cells

The synthesis, biophysical and biological evaluation of a series of G-quadruplex interacting small molecules based on a N,N′-bis(quinolinyl) pyridine-2,6-dicarboxamide scaffold is described. The synthetic analogues were evaluated for their ability to stabilize telomeric G-quadruplex DNA, some of which showed very high stabilization potential associated with high selectivity over double-stranded DNA. The compounds exhibited growth arrest of cancer cells with detectable selectivity over normal cells. Long-time growth arrest was accompanied by senescence, where telomeric dysfunction is a predominant mechanism together with the accumulation of restricted DNA damage sites in the genome. Our data emphasize the potential of a senescence-mediated anticancer therapy through the use of G-quadruplex targeting small molecules based on the molecular framework of pyridostatin.