147283-34-9

Basic information

• Product Name: 2-(3-amino-2-oxo-6-phenyl-1,2-dihydro-1-pyridyl)-N-<2-<(tert-butyldimethylsilyl)oxy>-3,3,3-trifluoro-1-isopropylpropyl>acetamide
• Synonyms: 2-(3-amino-2-oxo-6-phenyl-1,2-dihydro-1-pyridyl)-N-<2-<(tert-butyldimethylsilyl)oxy>-3,3,3-trifluoro-1-isopropylpropyl>acetamide
• CAS NO: 147283-34-9
• Molecular Weight: 511.66
• Mol File: 147283-34-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-(3-amino-2-oxo-6-phenyl-1,2-dihydro-1-pyridyl)-N-<2-<(tert-butyldimethylsilyl)oxy>-3,3,3-trifluoro-1-isopropylpropyl>acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3-amino-2-oxo-6-phenyl-1,2-dihydro-1-pyridyl)-N-<2-<(tert-butyldimethylsilyl)oxy>-3,3,3-trifluoro-1-isopropylpropyl>acetamide(147283-34-9)
• EPA Substance Registry System: 2-(3-amino-2-oxo-6-phenyl-1,2-dihydro-1-pyridyl)-N-<2-<(tert-butyldimethylsilyl)oxy>-3,3,3-trifluoro-1-isopropylpropyl>acetamide(147283-34-9)

Safety Data

• Hazardous Substances Data: 147283-34-9(Hazardous Substances Data)

Upstream product

• 147269-02-1 2-<3-<(benzyloxycarbonyl)amino>-2-oxo-6-phenyl-1,2-dihydro-1-pyridyl>-N-<2-<(tert-butyldimethylsilyl)oxy>-3,3,3-trifluoro-1-isopropylpropyl>acetamide 
• 2142-68-9 1-(2-chlorophenyl)ethanone 
• 147313-49-3 2-[3-benzyloxycarbonylamino-6-(2-chlorophenyl)-2-oxo-1,2-dihydro-1-pyridyl]-N-(2-tert-butyldimethylsilyloxy-3,3,3-trifluoro-1-isopropylpropyl)acetamide 
• 147313-48-2 benzyl 6-(2-chlorophenyl)-2-oxo-1,2-dihydropyridin-3-ylcarbamate 
• 147269-01-0 3-benzyloxycarbonylamino-6-phenylpyrid-2-one 
• 147283-47-4 6-(2-chlorophenyl)pyrid-2-one-3-carboxylic acid 
• 147283-46-3 6-(2-chlorophenyl)-2-oxo-1,2-dihydropyridine-3-carbonitrile 
• 147283-20-3 N-(2-tert-Butyldimethylsilyloxy-3,3,3-trifluoro-1-isopropyl-propyl)-2-chloroacetamide 
• 147269-05-4 N-(2-tert-Butyldimethylsilyloxy-3,3,3-trifluoro-1-isopropyl-propyl)-2-iodoacetamide 
• 147269-04-3 2-chloro-N-(3,3,3-trifluoro-2-hydroxy-1-isopropylpropyl)acetamide 
• 56162-63-1 2-oxo-6-phenyl-1,2-dihydropyridine-3-carboxylic acid 
• 43083-13-2 1,2-dihydro-2-oxo-6-phenylpyridine-3-carbonitrile 
• 106746-09-2 3(RS)-amino-1,1,1-trifluoro-2(RS)-hydroxy-4-methylpentane hydrochloride 
• 69739-34-0 t-butyldimethylsiyl triflate 

Downstream Products

• 147284-53-5 N-(1-{[2-(tert-Butyl-dimethyl-silanyloxy)-3,3,3-trifluoro-1-isopropyl-propylcarbamoyl]-methyl}-2-oxo-6-phenyl-1,2-dihydro-pyridin-3-yl)-2,2,2-trifluoro-acetamide 
• 147284-80-8 N-[2-(tert-Butyl-dimethyl-silanyloxy)-3,3,3-trifluoro-1-isopropyl-propyl]-2-[3-(2-morpholin-4-yl-acetylamino)-2-oxo-6-phenyl-2H-pyridin-1-yl]-acetamide 
• 147284-33-1 N-[2-(tert-Butyl-dimethyl-silanyloxy)-3,3,3-trifluoro-1-isopropyl-propyl]-2-{3-[2-(2,5-dioxo-pyrrolidin-1-yl)-acetylamino]-2-oxo-6-phenyl-2H-pyridin-1-yl}-acetamide 
• 147313-47-1 N-(1-{[2-(tert-Butyl-dimethyl-silanyloxy)-3,3,3-trifluoro-1-isopropyl-propylcarbamoyl]-methyl}-2-oxo-6-phenyl-1,2-dihydro-pyridin-3-yl)-4-methoxy-benzamide 
• 147269-34-9 2-(3-Acetylamino-2-oxo-6-phenyl-2H-pyridin-1-yl)-N-[2-(tert-butyl-dimethyl-silanyloxy)-3,3,3-trifluoro-1-isopropyl-propyl]-acetamide 
• 1026263-16-0 (1-{[2-(tert-Butyl-dimethyl-silanyloxy)-3,3,3-trifluoro-1-isopropyl-propylcarbamoyl]-methyl}-2-oxo-6-phenyl-1,2-dihydro-pyridin-3-yl)-carbamic acid methyl ester 
• 147283-39-4 2-<3-(benzylureido)-2-oxo-6-phenyl-1,2-dihydro-1-pyridyl>-N-<2-<(tert-butyldimethylsilyl)oxy>-3,3,3-trifluoro-1-isopropylpropyl>acetamide 
• 147283-35-0 N-<2-<(tert-butyldimethylsilyl)oxy>-3,3,3-trifluoro-1-isopropylpropyl>-2-<2-oxo-6-phenyl-3-<(phenylacetyl)amino>-1,2-dihydro-1-pyridyl>acetamide 
• 147284-46-6 N-{2-Oxo-6-phenyl-1-[(3,3,3-trifluoro-2-hydroxy-1-isopropyl-propylcarbamoyl)-methyl]-1,2-dihydro-pyridin-3-yl}-oxalamic acid methyl ester 
• 147284-57-9 2,2,2-Trifluoro-N-{2-oxo-6-phenyl-1-[(3,3,3-trifluoro-2-hydroxy-1-isopropyl-propylcarbamoyl)-methyl]-1,2-dihydro-pyridin-3-yl}-acetamide 
• 147283-36-1 2-<2-oxo-6-phenyl-3-<(phenylacetyl)amino>-1,2-dihydro-1-pyridyl>-N-(3,3,3-trifluoro-2-hydroxy-1-isopropylpropyl)acetamide 
• 147268-60-8 N-{2-Oxo-6-phenyl-1-[(3,3,3-trifluoro-1-isopropyl-2-oxo-propylcarbamoyl)-methyl]-1,2-dihydro-pyridin-3-yl}-oxalamic acid methyl ester 
• 147283-43-0 4-Methoxy-N-{2-oxo-6-phenyl-1-[(3,3,3-trifluoro-2-hydroxy-1-isopropyl-propylcarbamoyl)-methyl]-1,2-dihydro-pyridin-3-yl}-benzamide 
• 147268-81-3 2-(3-trifluoroacetylamino-2-oxo-6-phenyl-1,2-dihydro-1-pyridyl)-N-(3,3,3-trifluoro-1-isopropyl-2-oxopropyl)acetamide 

Relevant articles and documents

Heterocyclic amides

-

Nonpeptidic Inhibitors of Human Leukocyte Elastase. 3. Design, Synthesis, X-ray Crystallographic Analysis, and Structure-Activity Relationships for a Series of Orally Active 3-Amino-6-phenylpyridin-2-one Trifluoromethyl Ketones

A series of nonpeptidic inhibitors of human leukocyte elastase (HLE) is reported.These trifluoromethyl ketone-based inhibitors contain a 3-amino-6-phenylpyridone group as a central template.The effect of varying the N-3 substituent in these inhibitors on