43083-13-2

Basic information

• Product Name: 2-OXO-6-PHENYL-1,2-DIHYDRO-3-PYRIDINECARBONITRILE
• Synonyms: 2-OXO-6-PHENYL-1,2-DIHYDRO-3-PYRIDINECARBONITRILE;3-Cyano-2-hydroxy-6-phenylpyridine;2-keto-6-phenyl-1H-pyridine-3-carbonitrile;2-oxo-6-phenyl-1H-pyridine-3-carbonitrile;2-Hydroxy-6-phenylpyridine-3-carbonitrile;2-oxo-6-phenyl-1,2-dihydropyridine-3-carbonitrile
• CAS NO: 43083-13-2
• Molecular Formula: C₁₂H₈N₂O
• Molecular Weight: 196.2
• Mol File: 43083-13-2.mol
• Article Data: 14

Chemical Properties

• Melting Point: 353-355°
• Boiling Point: 437°Cat760mmHg
• Flash Point: 218.1°C
• Appearance: /
• Density: 1.26g/cm³
• Vapor Pressure: 7.74E-08mmHg at 25°C
• Refractive Index: 1.636
• PKA: 7.73±0.10(Predicted)
• CAS DataBase Reference: 2-OXO-6-PHENYL-1,2-DIHYDRO-3-PYRIDINECARBONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-OXO-6-PHENYL-1,2-DIHYDRO-3-PYRIDINECARBONITRILE(43083-13-2)
• EPA Substance Registry System: 2-OXO-6-PHENYL-1,2-DIHYDRO-3-PYRIDINECARBONITRILE(43083-13-2)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 43083-13-2(Hazardous Substances Data)

Usage

General Description

2-Oxo-6-Phenyl-1,2-Dihydro-3-Pyridinecarbonitrile is a chemical compound with the molecular formula C14H10N2O. It belongs to the category of organic compounds known as phenylpyridines, which are polycyclic aromatic compounds containing a benzene ring linked to a pyridine ring through a CC or CN bond. This chemical is not widely discussed in literature, thus information on its applications or uses is not readily available. However, it might find uses in pharmaceutical or chemical research due to its structural properties. As with most chemicals, proper safety measures should be observed in handling 2-Oxo-6-Phenyl-1,2-Dihydro-3-Pyridinecarbonitrile to protect from potential hazards.

InChI:InChI=1/C12H8N2O/c13-8-10-6-7-11(14-12(10)15)9-4-2-1-3-5-9/h1-7H,(H,14,15)

Upstream product

• 41125-10-4 benzoylacetaldehyde sodium salt 
• 98-86-2 acetophenone 
• 107-91-5 cyanoacetic acid amide 
• 109-94-4 formic acid ethyl ester 
• 121017-84-3 5-cyano-6-oxo-2-phenyl-1,6-dihydropyridine-3-carboxylic acid 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 42731-38-4 (2Z)-3-hydroxy-1-phenyl-2-propen-1-one sodium salt 
• 1131-80-2 (E)-3-(N,N-dimethylamino)-1-phenyl-2-propen-1-one 
• 1201-93-0 1-phenyl-3-dimethylaminoprop-2-enone 
• 66129-60-0 ethyl-3-(dimethylamino)-2-(phenylcarbonyl)prop-2-enoate 
• 121017-78-5 5-Cyano-6-oxo-2-phenyl-1,6-dihydro-pyridine-3-carboxylic acid ethyl ester 
• 54818-68-7 2-cyano-5-dimethylamino-5-phenylpenta-2,4-dienoic acid amide 

Downstream Products

• 339109-23-8 1-Methyl-2-oxo-6-phenyl-1,2-dihydro-pyridine-3-carbonitrile 
• 85814-99-9 2-methoxy-6-phenylpyridine-3-carbonitrile 
• 56162-63-1 6-phenyl-2-hydroxypyridine-3-carboxylic acid 
• 43083-14-3 2-chloro-3-cyano-6-phenylpyridine 
• 85830-29-1 6-Phenyl-3-(1H-tetrazol-5-yl)-pyridin-2-ol 
• 56162-63-1 2-oxo-6-phenyl-1,2-dihydropyridine-3-carboxylic acid 
• 1228182-75-9 5-bromo-2-chloro-6-phenyl-nicotinonitrile 
• 583039-87-6 5-bromo-6-phenyl-1H-pyrazolo[3,4-b]pyridin-3-ylamine 
• 147269-01-0 3-benzyloxycarbonylamino-6-phenylpyrid-2-one 
• 147283-34-9 2-(3-amino-2-oxo-6-phenyl-1,2-dihydro-1-pyridyl)-N-<2-<(tert-butyldimethylsilyl)oxy>-3,3,3-trifluoro-1-isopropylpropyl>acetamide 
• 147269-03-2 2-<3-<(benzyloxycarbonyl)amino>-2-oxo-6-phenyl-1,2-dihydro-1-pyridyl>-N-(3,3,3-trifluoro-2-hydroxy-1-isopropylpropyl)acetamide 
• 147267-17-2 2-<3-<(benzyloxycarbonyl)amino>-2-oxo-6-phenyl-1,2-dihydro-1-pyridyl>-N-(3,3,3-trifluoro-1-isopropyl-2-oxopropyl)acetamide 

Relevant articles and documents

2-Chloro-3-cyano-6-phenylpyridine

The molecular structure of the title compound (2-chloro-6-phenylpyridine-3-carbonitrile, C12H7ClN2) is presented. The molecule is nearly planar. Despite strong substituent interactions, the aromaticity of the pyridine frag

Base-catalysed 18F-labelling of trifluoromethyl ketones. Application to the synthesis of 18F-labelled neutrophil elastase inhibitors

A new method for the fluorine-18 labelling of trifluoromethyl ketones has been developed. This method is based on the conversion of a-COCF3 functional group to a difluoro enol silyl ether followed by halogenation and fluorine-18 labelling. The utility of this new method was demonstrated by the synthesis of fluorine-18 labelled neutrophil elastase inhibitors, which are potentially useful for detection of inflammatory disorders.

Discovery and structure-activity relationships study of novel thieno[2,3-b]pyridine analogues as hepatitis C virus inhibitors

Current treatment for hepatitis C is barely satisfactory, there is an urgent need to develop novel agents for combating hepatitis C virus infection. This study discovered a new class of thieno[2,3-b]pyridine derivatives as HCV inhibitors. First, a hit compound characterized by a thienopyridine core was identified in a cell-based screening of our privileged small molecule library. And then, structure activity relationship study of the hit compound led to the discovery of several potent compounds without obvious cytotoxicity in vitro (12c, EC50 = 3.3 μM, SI >30.3, 12b, EC50 = 3.5 μM, SI >28.6, 10l, EC50 = 3.9 μM, SI >25.6, 12o, EC 50 = 4.5 μM, SI >22.2, respectively). Although the mechanism of them had not been clearly elucidated, our preliminary optimization of this class of compounds had provided us a start point to develop new anti-HCV agents.