147377-67-1Relevant articles and documents
Squaramide-catalyzed asymmetric intramolecular oxa-michael reaction of α,β-unsaturated carbonyls containing benzyl alcohol: Construction of chiral 1-substituted phthalans
Son, Eun Chae,Kim, Seung Yeon,Kim, Sung-Gon
, p. 6826 - 6839 (2021/05/29)
Organocatalytic enantioselective intramolecular oxa-Michael reactions of benzyl alcohol bearing α,β-unsaturated carbonyls as Michael acceptors are presented herein. Using cinchona squaramide-based organocatalyst, enones as well as α,βunsaturated esters containing benzyl alcohol provided their corresponding 1,3-dihydroisobenzofuranyl-1-methylene ketones and 1,3-dihydroisobenzofuranyl-1-methylene esters in excellent yields with high enantioselectivities. In addition, enantioenriched 1,3-dihydroisobenzofuranyl-1-methylene ketone could be obtained from the Wittig/oxa-Michael reaction cascade of 1,3-dihydro-2-benzofuran-1-ol.
A General Synthetic Route to Fused Furans. Total Synthesis of (+)-Pallescensin A
Shishido, Kozo,Umimoto, Koji,Ouchi, Mikiko,Irie, Osamu,Omodani, Tomoki,et al.
, p. 328 - 375 (2007/10/02)
A general and facile synthetic route to fused furans has been developed.The key step of the transformation involves the intramolecular dipolar cycloaddition reaction of the nitrile oxides, 2 and 2', which were generated in situ from the correspondin