147976-16-7

Basic information

• Product Name: (4S,5S)-5-hydroxymethyl-4-phenylmethyloxazolidinone
• Synonyms: (4S,5S)-5-hydroxymethyl-4-phenylmethyloxazolidinone
• CAS NO: 147976-16-7
• Molecular Weight: 207.229
• Mol File: 147976-16-7.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: (4S,5S)-5-hydroxymethyl-4-phenylmethyloxazolidinone(CAS DataBase Reference)
• NIST Chemistry Reference: (4S,5S)-5-hydroxymethyl-4-phenylmethyloxazolidinone(147976-16-7)
• EPA Substance Registry System: (4S,5S)-5-hydroxymethyl-4-phenylmethyloxazolidinone(147976-16-7)

Safety Data

• Hazardous Substances Data: 147976-16-7(Hazardous Substances Data)

Upstream product

• 147915-01-3 (2S,3S)-3-azido-1,2-O-methylethylidene-4-phenylbutane-1,2-diol 
• 165727-45-7 tert-butyl ((2S,3S)-4-chloro-3-hydroxy-1-phenylbutan-2-yl)carbamate 
• 478866-50-1 (4S,5R)-4-benzyl-5-(chloromethyl)oxazolidin-2-one 
• 7664-93-9 sulfuric acid 
• 147976-18-9 (4S,5S)-4-benzyl-2-oxo-oxazolidine-5-carboxylic acid 
• 140867-27-2 (2R,3R)-1,2-O-methylethylidene-4-phenylbutane-1,2,3-triol 
• 116949-67-8 (2S,3S)-2-azido-1-phenyl-butane-3,4-diol 
• 591-51-5 phenyllithium 
• 161525-75-3 (2S,3S)-2-hydroxy-3-phthalimido-4-phenylbutyronitrile 
• 63-91-2 L-phenylalanine 
• 32150-91-7 phthaloyl-L-phenylalanyl chloride 
• 5123-55-7 Nα-phthaloyl-L-phenylalanine 
• 55722-86-6 (2S)-1-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-phenylpropanal 
• 229159-10-8 (2S,3S)-2-Benzyl-3,4-dihydroxy-butyramide 

Downstream Products

• 98760-08-8 (1-oxiranyl-2-phenylethyl)carbamic acid tert-butyl ester 
• 127779-20-8 Saquinavir 
• 136522-17-3 cis-N-butyldecahydro-2-<2(R)-hydroxy-4-phenyl-3(S)-aminobutyl>-(4aS,8aS)-isoquinoline-3(S)-carboxamide 
• 137431-06-2 2-[3(S)-[(L-asparaginyl)-amino]-2(R)-hydroxy-4-phenylbutyl]-N-tert-butyl-decahydro(4aS,8aS)-isoquinoline-3(S)-carboxamide 
• 136522-18-4 2-<3(S)-<amino>-2(R)-hydroxy-4-phenylbutyl>-N-tert-butyldecahydro-(4aS,8aS)-isoquinoline-3(S)-carboxamide 
• 162221-49-0 p-bromobenzenesulphonic acid (4S,5S)-4-benzyl-2-oxo-oxazolidin-5-yl methyl ester 
• 162221-36-5 (4S,5S)-4-benzyl-2-oxo-oxazolidine-5-carboxylic acid methyl ether 
• 162221-28-5 4-Nitro-benzenesulfonic acid (4S,5S)-4-benzyl-2-oxo-oxazolidin-5-ylmethyl ester 
• 147976-18-9 (4S,5S)-4-benzyl-2-oxo-oxazolidine-5-carboxylic acid 

Relevant articles and documents

Stereoselective synthesis of protected amino alkyl epoxides

The mechanism of epoxidation of chiral allyl amines has been investigated. The intrinsic stereoselectivity for epoxidation is shown to be approximately 5:1 and is independent of the nitrogen substituent. However, the nature of the N-protecting group influences the stability of the undesired epoxide to the acidic media, with the minor diastereomer undergoing preferential decomposition. Conditions are reported for the highly stereoselective synthesis of epoxide 9R, an important building block in the synthesis of several enzyme inhibitors.

Facile synthetic route to (2S,3S)-3-amino-2-hydroxy-4-phenylbutyric acid and its derivatives, the key intermediates for HIV protease inhibitors

A facile and efficient route to (2S,3S)-3-amino-2-hydroxy-4-phenylbutyric acid and its derivative (4S,5S)-4-benzyl-5-hydroxymethyl oxazolidin-2-one is presented. N-phthaloyl protected L-phenylalanine 1 was treated with thionyl chloride followed by hydroge

Synthesis of N-BOC-3-amino-1,2-epoxy-4-phenylbutane from (3S)-hydroxy-γ-butyrolactone by means of the Hofmann rearrangement

The stereocontrolled synthesis of the title alkylaminoepoxide was achieved starting from (3S)-hydroxy-γ-butyrolactone by efficient utilization of the Hofmann rearrangement followed by intramolecular oxazolidinone ring formation as a key step.