148146-56-9

Basic information

• Product Name: ascomycin 32-triflate
• Synonyms: ascomycin 32-triflate
• CAS NO: 148146-56-9
• Molecular Weight: 924.083
• Mol File: 148146-56-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: ascomycin 32-triflate(CAS DataBase Reference)
• NIST Chemistry Reference: ascomycin 32-triflate(148146-56-9)
• EPA Substance Registry System: ascomycin 32-triflate(148146-56-9)

Safety Data

• Hazardous Substances Data: 148146-56-9(Hazardous Substances Data)

Upstream product

• 358-23-6 trifluoromethylsulfonic anhydride 
• 135635-46-0 ascomycin 

Downstream Products

• 137071-32-0 pimecrolimus 

Relevant articles and documents

METHODS FOR PREPARING PIMECROLIMUS

The present invention provides a process for the preparation of pimecrolimus from ascomycin in which ascomycin is reacted with a conversion reagent that converts ascomycin to its activated derivative at C-32. The activated ascomycin is then reacted with chloride ion. The process of the invention requires fewer process steps than prior art processes, and does not require the protection of the ascomycin C-24 hydroxyl group or the purification of the activated ascomycin derivative.