148494-90-0 Usage
Description
1-Phenylpiperidin-3-one is an organic compound with a molecular structure that features a piperidine ring fused to a phenyl group. It is a key intermediate in the synthesis of various pharmaceutical compounds and has potential applications in the development of new drugs.
Uses
Used in Pharmaceutical Industry:
1-Phenylpiperidin-3-one is used as a synthetic intermediate for the development of compounds with lipoxygenase inhibition properties. Lipoxygenase enzymes are involved in various physiological processes and are associated with inflammation and other diseases. By inhibiting these enzymes, 1-Phenylpiperidin-3-one can contribute to the creation of medications that target inflammation and related conditions.
Additionally, 1-Phenylpiperidin-3-one may have potential applications in other industries, such as chemical or materials science, depending on its specific properties and characteristics. However, based on the provided materials, the primary use of 1-Phenylpiperidin-3-one is in the pharmaceutical industry for the synthetic preparation of lipoxygenase inhibition structures.
Check Digit Verification of cas no
The CAS Registry Mumber 148494-90-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,8,4,9 and 4 respectively; the second part has 2 digits, 9 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 148494-90:
(8*1)+(7*4)+(6*8)+(5*4)+(4*9)+(3*4)+(2*9)+(1*0)=170
170 % 10 = 0
So 148494-90-0 is a valid CAS Registry Number.
InChI:InChI=1/C11H13NO/c13-11-7-4-8-12(9-11)10-5-2-1-3-6-10/h1-3,5-6H,4,7-9H2
148494-90-0Relevant articles and documents
Origin of the E/Z Selectivity in the Synthesis of Tetrasubstituted Olefins by Wittig Reaction of α-Fluorophosphonium Ylides: An Explanation for the Low Stereoselectivity Observed in Reactions of α-Alkoxy Aldehydes
Depré, Dominique,Vermeulen, Wim A. A.,Lang, Yolande,Dubois, Jean,Vandevivere, Jan,Vandermeersch, Jeremy,Huang, Longchuan,Robiette, Rapha?l
supporting information, p. 1414 - 1417 (2017/03/23)
A series of tetrasubstituted fluoroalkenes were synthesized in good yield and high E/Z selectivity (up to 96/4) by Wittig reaction between α-heterosubstituted ketones and α-fluorophosphonium ylides. A detailed study of factors that control stereoselectivity in these reactions shows that stereoselectivity is the result of stabilizing CH···F and N···C=O interactions in the addition TS leading to the E isomer. This analysis provides a rationale for the observed decrease in selectivity for reactions of stabilized ylides with α-alkoxy aldehydes.
