765962-69-4

Basic information

• Product Name: 3,3-diMethoxyPiperidine
• Synonyms: 3,3-diMethoxyPiperidine
• CAS NO: 765962-69-4
• Molecular Formula: C₇H₁₅NO₂
• Molecular Weight: 145.1995
• Mol File: 765962-69-4.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 177.3±40.0 °C(Predicted)
• Appearance: /
• Density: 0.99±0.1 g/cm3(Predicted)
• PKA: 8.26±0.10(Predicted)
• CAS DataBase Reference: 3,3-diMethoxyPiperidine(CAS DataBase Reference)
• NIST Chemistry Reference: 3,3-diMethoxyPiperidine(765962-69-4)
• EPA Substance Registry System: 3,3-diMethoxyPiperidine(765962-69-4)

Safety Data

• Hazardous Substances Data: 765962-69-4(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 98977-36-7 3-oxo-piperidine-1-carboxylic acid tert-butyl ester 

Downstream Products

• 1428976-11-7 3,3-dimethoxy-N-phenethylpiperidine 
• 1428976-05-9 C₁₈H₁₉NO*ClH 
• 1428976-06-0 C₁₃H₁₇NO₂*ClH 
• 1428976-07-1 C₁₃H₁₇NO₂*ClH 
• 1428976-33-3 ethyl 2-(1-benzhydrylpiperidin-3-ylidene)-2-fluoroacetate 
• 1428976-32-2 ethyl 2-(1-benzhydrylpiperidin-3-ylidene)-2-fluoroacetate 
• 144872-34-4 1-(4-nitrophenyl)piperidin-3-one 
• 148494-90-0 (2S)-phenyl-3-piperidone 
• 916991-29-2 1-(4-methoxy-phenyl)-piperidin-3-one 

Relevant articles and documents

Origin of the E/Z Selectivity in the Synthesis of Tetrasubstituted Olefins by Wittig Reaction of α-Fluorophosphonium Ylides: An Explanation for the Low Stereoselectivity Observed in Reactions of α-Alkoxy Aldehydes

A series of tetrasubstituted fluoroalkenes were synthesized in good yield and high E/Z selectivity (up to 96/4) by Wittig reaction between α-heterosubstituted ketones and α-fluorophosphonium ylides. A detailed study of factors that control stereoselectivity in these reactions shows that stereoselectivity is the result of stabilizing CH···F and N···C=O interactions in the addition TS leading to the E isomer. This analysis provides a rationale for the observed decrease in selectivity for reactions of stabilized ylides with α-alkoxy aldehydes.