148547-94-8

Basic information

• Product Name: methyl 2,3-dibromo-3-p-tolylpropionic acid methyl ester
• Synonyms: methyl 2,3-dibromo-3-p-tolylpropionic acid methyl ester
• CAS NO: 148547-94-8
• Molecular Weight: 336.023
• Mol File: 148547-94-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: methyl 2,3-dibromo-3-p-tolylpropionic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2,3-dibromo-3-p-tolylpropionic acid methyl ester(148547-94-8)
• EPA Substance Registry System: methyl 2,3-dibromo-3-p-tolylpropionic acid methyl ester(148547-94-8)

Safety Data

• Hazardous Substances Data: 148547-94-8(Hazardous Substances Data)

Upstream product

• 7560-43-2 methyl 3-(4-methylphenyl)acrylate 
• 1866-39-3 4-methylcinnamic acid 
• 104-87-0 4-methyl-benzaldehyde 
• 21204-67-1 methyl (triphenylphosphoranylidene)acetate 
• 52916-86-6 (2RS,3SR)-2,3-dibromo-3-(4-methylphenyl)propanoic acid 

Downstream Products

• 7515-16-4 methyl 3-(4-methylphenyl)prop-2-ynoate 
• 2227-58-9 3-(4-methylphenyl)prop-2-ynoic acid 
• 20754-20-5 3-p-tolyl-acrylic acid methyl ester 
• 182884-68-0 (Z)-methyl 2-bromo-3-(p-tolyl)propenoate 
• 140473-84-3 (E)-methyl 2-bromo-3-(p-tolyl)propenoate 
• 182884-62-4 (Z)-2-bromo-3-(p-tolyl)propenoic acid 

Relevant articles and documents

Synthesis and antibacterial evaluation of novel 11-O-aralkylcarbamoyl-3-O-descladinosylclarithromycin derivatives

A series of novel 11-O-aralkylcarbamoyl-3-O-descladinosylclarithromycin derivatives were designed, synthesized and evaluated for their in vitro antibacterial activity. The results showed that the majority of the target compounds displayed potent activity against erythromycin-susceptible S. pyogenes, erythromycin-resistant S. pneumoniae A22072 expressing the mef gene and S. pneumoniae AB11 expressing the mef and erm genes. Besides, most of the target compounds exhibited moderate activity against erythromycin-susceptible S. aureus ATCC25923 and B. subtilis ATCC9372. In particular, compounds 11a, 11b, 11c, 11e, 11f and 11h were found to exert favorable antibacterial activity against erythromycin-susceptible S. pyogenes with the MIC values of 0.015–0.125 μg/mL. Furthermore, compounds 10e, 11a, 11b and 11c showed superior activity against erythromycin-resistant S. pneumoniae A22072 with the MIC values of 0.25–0.5 μg/mL. Additionally, compound 11c was the most effective against all the erythromycin-resistant S. pneumoniae strains (A22072, B1 and AB11), exhibiting 8-, 8- and 32-fold more potent activity than clarithromycin, respectively.

Triphenylphosphine oxide-catalyzed stereoselective poly- and dibromination of unsaturated compounds

A novel PPh3O catalyzed bromophosphonium salt-mediated dibromination of α,β-unsaturated esters and β,γ- unsaturated α-ketoesters has been developed. The products were obtained with good to excellent yields and excellent diastereoselectivities.