14933-24-5

Basic information

• Product Name: 3-bromo-2-hydroxyquinolin-4(1H)-one
• Synonyms: 3-bromo-4-hydroxy-1,2-dihydroquinolin-2-one
• CAS NO: 14933-24-5
• Molecular Formula: C₉H₆BrNO₂
• Molecular Weight: 240.0534
• Mol File: 14933-24-5.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 298.9°C at 760 mmHg
• Flash Point: 134.5°C
• Density: 1.854g/cm³
• Vapor Pressure: 0.000553mmHg at 25°C
• Refractive Index: 1.715
• CAS DataBase Reference: 3-bromo-2-hydroxyquinolin-4(1H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-bromo-2-hydroxyquinolin-4(1H)-one(14933-24-5)
• EPA Substance Registry System: 3-bromo-2-hydroxyquinolin-4(1H)-one(14933-24-5)

Safety Data

• Hazardous Substances Data: 14933-24-5(Hazardous Substances Data)

Upstream product

• 70254-44-3 2,4-dihydroxyquinoline 
• 70254-43-2 4-Hydroxy-2-quinolone 
• 7726-95-6 bromine 
• 64-19-7 acetic acid 
• 64-18-6 formic acid 
• 42712-64-1 2-amino-quinolin-4-ol 
• 86795-52-0 2-Oxo-3-phenyliodonium-1,2-dihydrochinolin-4-olat 

Downstream Products

• 109069-65-0 3-bromo-2,4-dichloroquinoline 
• 18693-11-3 3-phenylsulfanyl-quinoline-2,4-diol 
• 204642-78-4 2,4-dichloro-3-phenylsulfanyl-quinoline 
• 868145-21-5 4-(benzyloxy)-3-bromoquinolin-2(1H)-one 

Relevant articles and documents

HCV NS3 protease inhibitors

The present invention relates to macrocyclic compounds of formula (I) that are useful as inhibitors of the hepatitis C virus (HCV) NS3 protease, their synthesis, and their use for treating or preventing HCV infections.

Conformational analysis of tandospirone in aqueous solution: Lead evolution of potent dopamine D4 receptor ligands

The significant contribution of folded conformation (2) of the anxiolytic tandospirone (1) in aqueous solution was verified by dynamic 1H NMR. A structurally rigid mimic of 2 was designed and synthesized to evaluate the implication of 2 towards neuroleptic receptor binding. The designed structures provided a new rigid scaffold for dopamine D4 ligands.

Ylides of Heterocycles, VIII. Reactions of Iodonium-Ylides with Acids

The reaction of various organic and inorganic acids (HX) with iodonium ylides 2 leads to nucleophilic substitution of the iodobenzene substituent by the anion X(-) to yield the heterocycles 5.Some of them are hydrolyzed to the hydroxy compounds 3 or reduced to the starting compounds 1 under the reaction conditions.Reaction of the iodonium ylide 2b with monomethyl sulfate gives the salt 9, which with bases undergoes nucleophilic substitution to compounds 8 and 10-12, respectively, or is converted to 2b again. - Keywords: 3-Acetoxy-4-hydroxy-2-quinolones; 2-Oxoquinoline-4-olates; 3-Substituted 4-hydroxy-2-quinolones