1494-33-3

Basic information

• Product Name: 4-fluorobenzyl(4-methylphenyl)sulfane
• Synonyms: 4-fluorobenzyl(4-methylphenyl)sulfane
• CAS NO: 1494-33-3
• Molecular Weight: 232.322
• Mol File: 1494-33-3.mol
• Article Data: 12

Chemical Properties

• CAS DataBase Reference: 4-fluorobenzyl(4-methylphenyl)sulfane(CAS DataBase Reference)
• NIST Chemistry Reference: 4-fluorobenzyl(4-methylphenyl)sulfane(1494-33-3)
• EPA Substance Registry System: 4-fluorobenzyl(4-methylphenyl)sulfane(1494-33-3)

Safety Data

• Hazardous Substances Data: 1494-33-3(Hazardous Substances Data)

Upstream product

• 2943-42-2 di(4-methyl)phenylthiosulfonate 
• 51044-11-2 (4-fluorobenzyl)(triphenyl)phosphonium bromide 
• 824-79-3 sodium 4-methylbenzenesulfinate 
• 333-45-9 p-fluorobenzyltrimethylammonium bromide 
• 106-45-6 para-thiocresol 
• 459-56-3 4-fluorobenzylic alcohol 
• 459-44-9 4-methylbenzenediazonium tetrafluoroborate 
• 624-31-7 4-tolyl iodide 
• 15894-04-9 (4-fluorophenyl)methanethiol 
• 106-49-0 p-toluidine 
• 36651-88-4 N-(4-methylphenylazo)pyrrolidine 
• 352-11-4 1-chloromethyl-4-fluorobenzene 
• 10486-08-5 sodium p-thiocresolate 
• 459-46-1 4-Fluorobenzyl bromide 

Downstream Products

• 1512843-93-4 (E)-methyl 3-(5-fluoro-2-(p-tolylsulfinylmethyl)phenyl)acrylate 
• 1494-29-7 1-fluoro-4-(4-tolylsulfonylmethyl)benzene 
• 234080-54-7 C₂₀H₂₄BrFS 
• 1426-53-5 1-fluoro-4-((p-tolylsulfinyl)methyl)benzene 

Relevant articles and documents

Synthesis of benzyl thioether derivatives via N-heterocyclic carbene palladium(II)-catalyzed cross coupling of benzylammonium salts with thiophenols

A new route to benzyl thioether derivatives has been developed via the N-heterocyclic carbene palladium(II)-catalyzed cross coupling of benzylammonium salts with thiophenols. Under the optimal conditions, different benzylammonium salts could be well toler

Rhodium-Catalyzed C-H/C-H Cross Coupling of Benzylthioethers or Benzylamines with Thiophenes Enabled by Flexible Directing Groups

Reported herein is an efficient synthetic protocol to ortho-functionalized 2-aryl thiophenes via Rh(III)-catalyzed C-H/C-H cross coupling of benzylthioethers or benzylamines with thiophenes. Both ortho- and meta-substituted benzylthioethers give monoheteroarylated products, while ortho-unhindered substrates mainly provide diheteroarylated benzylthioethers. The C-H/C-H cross coupling of benzylamines with thiophenes exclusively generates diheteroarylated benzaldehydes. Mechanistic investigation discloses a three-step tandem process involving the ortho-C-H diheteroarylation of benzylamine, the oxidation of benzylamine to imine, and the hydrolysis of imine to aldehyde.

Aryl alkyl, aryl aryl thioether compound and its synthesis method

The invention discloses a synthesis method of an aryl-alkyl and aryl-aryl thioether compound represented by a formula (III). According to the synthesis method, aryl tetrafluoroboric acid diazonium salt is taken as a reaction raw material in a reaction solvent, aryl and alkyl thiosulfate is taken as a sulfurizing agent, and the materials react under the catalysis action of visible light and a photosensitive agent to obtain the aryl-alkyl and aryl-aryl thioether compound. According to the synthesis method, the raw materials are easy to obtain and are cheap, the reaction operation is simple, the reaction condition is mild and environment-friendly, the yield is higher, the functional group tolerance is excellent, later modification of drugs is successfully realized, and an efficient C-S bond construction method is provided for medicinal chemistry and biological orthogonal chemistry research.