149620-84-8

Basic information

• Product Name: 2-(2,3-dihydro-2-oxo-5-phenylbenzo[e][1,4]diazepin-1-yl) acetic acid
• Synonyms: 2-(2,3-dihydro-2-oxo-5-phenylbenzo[e][1,4]diazepin-1-yl) acetic acid
• CAS NO: 149620-84-8
• Molecular Weight: 294.31
• Mol File: 149620-84-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-(2,3-dihydro-2-oxo-5-phenylbenzo[e][1,4]diazepin-1-yl) acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2,3-dihydro-2-oxo-5-phenylbenzo[e][1,4]diazepin-1-yl) acetic acid(149620-84-8)
• EPA Substance Registry System: 2-(2,3-dihydro-2-oxo-5-phenylbenzo[e][1,4]diazepin-1-yl) acetic acid(149620-84-8)

Safety Data

• Hazardous Substances Data: 149620-84-8(Hazardous Substances Data)

Upstream product

• 2835-77-0 (2-aminophenyl)(phenyl)methanone 
• 14439-71-5 2'-benzoyl-2-bromo-acetanilide 
• 2898-08-0 2,3-dihydro-5-phenyl-1H-1,4-benzodiazepin-2-one 
• 497873-44-6 (2-oxo-5-phenyl-2,3-dihydrobenzo[e][1,4]diazepin-1-yl)acetic acid ethyl ester 
• 149620-85-9 tert-butyl 2-(2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e] [1,4] diazepin-1-yl)acetate 

Downstream Products

• 1623752-65-7 N-allyl-2-(2,3-dihydro-2-oxo-5-phenylbenzo[e][1,4]diazepin-1-yl)acetamide 
• 164336-12-3 3-amino-2,3-dihydro-5-phenyl-1H-1,4-benzodiazepin-2-one-1-acetic acid 
• 164336-14-5 3-(tert-butoxycarbonyl)methylamino-2,3-dihydro-5-phenyl-1H-1,4-benzodiazepin-2-one-1-acetic acid 
• 164336-13-4 (3-tert-butoxycarbonylamino-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-1-yl)acetic acid 
• 162823-37-2 3-oximino-2,3-dihydro-5-phenyl-1H-1,4-benzodiazepin-2-one-1-acetic acid 

Relevant articles and documents

Synthesis and biological evaluation of papain-family cathepsin l-like cysteine protease inhibitors containing a 1,4-benzodiazepine scaffold as antiprotozoal agents

Novel papain-family cathepsin L-like cysteine protease inhibitors endowed with antitrypanosomal and antimalarial activity were developed, through an optimization study of previously developed inhibitors. In the present work, we studied the structure-activity relationships of these derivatives, with the aim to develop new analogues with a simplified and more synthetically accessible structure and with improved antiparasitic activity. The structure of the model compounds was significantly simplified by modifying or even eliminating the side chain appended at the C3 atom of the benzodiazepine scaffold. In addition, a simple methylene spacer of appropriate length was inserted between the benzodiazepine ring and the 3-bromoisoxazoline moiety. Several rhodesain and falcipain-2 inhibitors displaying single-digit micromolar or sub-micromolar antiparasitic activity against one or both parasites were identified, with activities that were one order of magnitude more potent than the model compounds.

RAS FARNESYL TRANSFERASE INHIBITORS

Benzodiazepine derivatives are disclosed that act as potent inhibitors of ras famesyl:protein transferase. Pharrnaceutical compositions containing these benzodiazepines are provided for treatment of diseases for which inhibition of the ras farnesyl:protein transferase is indicated. Also disclosed are benzazepines of the following general formula (II) having similar utility as the aforementioned benzodiazepines