164336-13-4

Basic information

• Product Name: 1H-1,4-Benzodiazepine-1-acetic acid, 3-[[(1,1-dimethylethoxy)carbonyl]amino]-2,3-dihydro-2-oxo-5-phenyl-
• CAS NO: 164336-13-4
• Molecular Formula: C22H23N3O5
• Molecular Weight: 409.442
• Mol File: 164336-13-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1H-1,4-Benzodiazepine-1-acetic acid, 3-[[(1,1-dimethylethoxy)carbonyl]amino]-2,3-dihydro-2-oxo-5-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-1,4-Benzodiazepine-1-acetic acid, 3-[[(1,1-dimethylethoxy)carbonyl]amino]-2,3-dihydro-2-oxo-5-phenyl-(164336-13-4)
• EPA Substance Registry System: 1H-1,4-Benzodiazepine-1-acetic acid, 3-[[(1,1-dimethylethoxy)carbonyl]amino]-2,3-dihydro-2-oxo-5-phenyl-(164336-13-4)

Safety Data

• Hazardous Substances Data: 164336-13-4(Hazardous Substances Data)

Upstream product

• 2898-08-0 2,3-dihydro-5-phenyl-1H-1,4-benzodiazepin-2-one 
• 149620-85-9 tert-butyl 2-(2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e] [1,4] diazepin-1-yl)acetate 
• 162823-37-2 3-oximino-2,3-dihydro-5-phenyl-1H-1,4-benzodiazepin-2-one-1-acetic acid 
• 149620-84-8 2-(2,3-dihydro-2-oxo-5-phenylbenzo[e][1,4]diazepin-1-yl) acetic acid 
• 14439-71-5 2'-benzoyl-2-bromo-acetanilide 
• 164336-12-3 3-amino-2,3-dihydro-5-phenyl-1H-1,4-benzodiazepin-2-one-1-acetic acid 
• 24424-99-5 di-tert-butyl dicarbonate 
• 821800-04-8 [(2-benzoyl-phenylcarbamoyl)propylsulfanylmethyl]carbamic acid benzyl ester 
• 168162-29-6 (2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)carbamic acid tert-butyl ester 
• 2835-77-0 (2-aminophenyl)(phenyl)methanone 
• 103343-47-1 3-amino-5-phenyl-1,3-dihydrobenzo[e][1,4]diazepin-2-one 
• 108895-97-2 2-α-(benzyloxycarbonyl)glycinyl)amino>benzophenone 
• 108895-98-3 benzyl 2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylcarbamate 
• 177784-09-7 (3-tert-butoxycarbonylamino-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-1-yl)acetic acid ethyl ester 

Downstream Products

• 164336-14-5 3-(tert-butoxycarbonyl)methylamino-2,3-dihydro-5-phenyl-1H-1,4-benzodiazepin-2-one-1-acetic acid 
• 821800-06-0 3(S)-acetylamino-N-{1-[((3S)-2-benzyloxy-5-oxo-tetrahydrofuran-3-ylcarbamoyl)methyl]-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl}succinamic acid benzyl ester 
• 821800-05-9 {1-[((3S)-2-benzyloxy-5-oxo-tetrahydrofuran-3-ylcarbamoyl)methyl]-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl}carbamic acid tert-butyl ester 

Relevant articles and documents

Design and synthesis of a potent and selective peptidomimetic inhibitor of caspase-3

In this paper we report the synthesis and characterization of a novel potent and selective inhibitor of caspase-3, a member of the caspase family of cysteine proteases which plays an important role in many human disorders. This molecule represents 3(S)-acetylamino-N-{1-[(((3S)-2-hydroxy-5-oxo- tetrahydrofuran-3-yl)carbamoyl)methyl]-2-oxo-5-phenyl-2,3-dihydro-1H/-benzo[e] [1,4]diazepin-3-yl}succinamic acid, a monocyclic conformationally constrained form of the tetrapeptide Ac-DEVD-H, in which a 1,4-benzodiazepine nucleus is introduced internally to the peptidic sequence.

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