149716-72-3 Usage
Description
(1R,2R,3S,5R)-Pinanediol Pyrrolidine-2R-boronate Hydrochloride is a complex organic compound with a unique molecular structure. It is characterized by its chiral centers at the 1R, 2R, 3S, and 5R positions, which contribute to its specific properties and potential applications in various fields.
Uses
Used in Pharmaceutical Industry:
(1R,2R,3S,5R)-Pinanediol Pyrrolidine-2R-boronate Hydrochloride is used as an intermediate in the synthesis of prolineboronate esters, which are important for the development of pharmaceutical compounds. These esters can be utilized in the creation of novel drugs with potential therapeutic applications, such as those targeting specific enzymes or receptors in the treatment of various diseases.
Used in Chemical Research:
In the field of chemical research, (1R,2R,3S,5R)-Pinanediol Pyrrolidine-2R-boronate Hydrochloride can serve as a valuable compound for studying the effects of chirality on molecular interactions and reactivity. Its unique structure allows researchers to explore the implications of stereochemistry in chemical reactions and develop a deeper understanding of the underlying principles governing these processes.
Used in Material Science:
The specific structural features of (1R,2R,3S,5R)-Pinanediol Pyrrolidine-2R-boronate Hydrochloride may also find applications in material science, where it could be used to develop new materials with tailored properties. For example, its chiral nature could be exploited to create materials with enhanced selectivity or specificity in various applications, such as sensors, catalysts, or drug delivery systems.
Check Digit Verification of cas no
The CAS Registry Mumber 149716-72-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,9,7,1 and 6 respectively; the second part has 2 digits, 7 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 149716-72:
(8*1)+(7*4)+(6*9)+(5*7)+(4*1)+(3*6)+(2*7)+(1*2)=163
163 % 10 = 3
So 149716-72-3 is a valid CAS Registry Number.
149716-72-3Relevant articles and documents
A practical synthesis of L-valyl-pyrrolidine-(2R)-boronic acid: Efficient recycling of the costly chiral auxiliary (+)-pinanediol
Gibson, Frank S.,Singh, Ambarish K.,Soumeillant, Maxime C.,Manchand, Percy S.,Humora, Michael,Kronenthal, David R.
, p. 814 - 816 (2002)
A practical synthesis of L-valyl-pyrrolidine-(2R)-boronic acid (1) is detailed. A previously disclosed synthesis of 1 (Snow, R.; Kelly, T. R.; Adams, J.; Coutts, S.; Perry, C. (Boehringer Ingelheim Pharmaceuticals, Inc.). WO 93/10127, 1993) was significantly improved by developing an efficient process for recycling the costly chiral auxiliary (+)- pinanediol.
Proline boric acid compound and preparation method and applications thereof
-
Paragraph 0048; 0049, (2019/01/06)
The invention provides a compound whose structure is shown as a formula (I) or a salt thereof. The compound is a proline boric acid proteasome inhibitor compound, and has good proteasome inhibitory activity and excellent druggability. The structural formula of the compound is shown as the formula (I).
Asymmetric synthesis of stable α-aminoboronic esters catalyzed by N-heterocylic carbene and copper(i) chloride
Chen, Jinbo,Chen, Ling-Yan,Zheng, Yue,Sun, Zhihua
, p. 21131 - 21133 (2014/06/09)
Bis(pinanediolato)diboron (B2pnd2) was used as the nucleophile instead of bis(pinacolato)diboron in the stereospecific synthesis of α-aminoboronic esters catalysed by a triazole-based N-hetereocyclic carbene (NHC) and Cu(i) chloride.
