149747-23-9

Basic information

• Product Name: 5-METHYL-4-P-TOLYL-4H-[1,2,4]TRIAZOLE-3-THIOL
• Synonyms: 5-METHYL-4-P-TOLYL-4H-[1,2,4]TRIAZOLE-3-THIOL;5-Methyl-4-(4-methylphenyl)-4H-1,2,4-triazole-3-thiol
• CAS NO: 149747-23-9
• Molecular Formula: C₁₀H₁₁N₃S
• Molecular Weight: 205.28
• Mol File: 149747-23-9.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-METHYL-4-P-TOLYL-4H-[1,2,4]TRIAZOLE-3-THIOL(CAS DataBase Reference)
• NIST Chemistry Reference: 5-METHYL-4-P-TOLYL-4H-[1,2,4]TRIAZOLE-3-THIOL(149747-23-9)
• EPA Substance Registry System: 5-METHYL-4-P-TOLYL-4H-[1,2,4]TRIAZOLE-3-THIOL(149747-23-9)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 149747-23-9(Hazardous Substances Data)

Upstream product

• 152473-68-2 1-acetyl-4-(4-methylphenyl)thiosemicarbazide 
• 13278-67-6 4-(4-methylphenyl)-3-thiosemicarbazide 
• 18871-66-4 N,N-dimethylacetamide dimethyl acetal 
• 622-59-3 1-isothiocyanato-4-methylbenzene 

Downstream Products

• 482661-10-9 N-(2-chloro-phenyl)-2-(5-methyl-4-p-tolyl-4H-[1,2,4]triazol-3-ylsulfanyl)-acetamide 

Relevant articles and documents

Antimicrobial and Physicochemical Characterizations of Thiosemicarbazide and S-Triazole Derivatives

Two series of thiosemicarbazide derivatives and three series of s-triazole derivatives have been synthesized. All of these compounds were tested for their in vitro antibacterial activity against Gram-positive and Gram-negative bacterial strains. Among tested thiosemicarbazide derivatives, the best bioactivity was detected for two 1-formylthiosemicarbazides with 3-/4-tolyl substitution (1 l, 1 m) (MICs range between 31.25 and 250 μg/mL). All tested s-triazole derivatives exhibited lower antibacterial activity than their acyclic precursors.

Tri-substituted triazoles as potent non-nucleoside inhibitors of the HIV-1 reverse transcriptase

A new series of 1,2,4-triazoles was synthesized and tested against several NNRTI-resistant HIV-1 isolates. Several of these compounds exhibited potent antiviral activities against efavirenz- and nevirapine-resistant viruses, containing K103N and/or Y181C mutations or Y188L mutation. Triazoles were first synthesized from commercially available substituted phenylthiosemicarbazides, then from isothiocyanates, and later by condensing the desired substituted anilines with thiosemicarbazones.