149792-13-2

Basic information

• Product Name: 1,4-bis((2-((Z-glycyl-glycyl-L-histidyl)amino)ethyl)amino)-5,8-dihydroxyanthracene-9,10-dione
• Synonyms: 1,4-bis((2-((Z-glycyl-glycyl-L-histidyl)amino)ethyl)amino)-5,8-dihydroxyanthracene-9,10-dione
• CAS NO: 149792-13-2
• Molecular Weight: 1127.14
• Mol File: 149792-13-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1,4-bis((2-((Z-glycyl-glycyl-L-histidyl)amino)ethyl)amino)-5,8-dihydroxyanthracene-9,10-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4-bis((2-((Z-glycyl-glycyl-L-histidyl)amino)ethyl)amino)-5,8-dihydroxyanthracene-9,10-dione(149792-13-2)
• EPA Substance Registry System: 1,4-bis((2-((Z-glycyl-glycyl-L-histidyl)amino)ethyl)amino)-5,8-dihydroxyanthracene-9,10-dione(149792-13-2)

Safety Data

• Hazardous Substances Data: 149792-13-2(Hazardous Substances Data)

Upstream product

• 3884-02-4 Z-glycyl-glycyl-L-histidine methyl ester 
• 149792-11-0 1,4-bis[Boc-aminoethylamino]-5,8-dihydroxyanthracene-9,10-dione 
• 4467-54-3 histidine methyl ester hydrochloride 
• 81-59-4 1,4,5,8-tetrahydroxy-2,3-dihydro-9,10-anthracenedione 
• 2566-19-0 CbzGlyGly 
• 52396-73-3 Z-glycyl-glycyl-L-histidine 

Relevant articles and documents

Synthesis and antitumor properties of an anthraquinone bisubstituted by the copper chelating peptide Gly-Gly-L-His

A new molecule 4 [(GGH-DAE)2DHQ] associating the 1,4,5,8- tetrahydroxyanthraquinone ring (DHQ) of the antitumor drug mitoxantrone (2), two diaminoethylene chains (DAE), and the metal-chelating peptide Gly-Gly- His (GGH) has been synthesized. Such a molecule presents characteristics able to induce antitumor activity: compound 4 intercalates into DNA as measured by ΔT(m), fluorescence quenching, and viscometry; ESR studies demonstrate that several types of Cu complexes are formed depending on pH; and the production of free radicals, as evidenced by spin-trapping, is enhanced by 4. In vitro, in leukemia cells L1210 and mammary cells MCF7, 4 is slightly less cytostatic than mitoxantrone, but substantially less toxic. In vivo, in leukemia P388 on mice, a T/C value of 230 is obtained at 25 mg/kg, higher than the one of mitoxantrone, which is toxic at the same dose.