150059-96-4

Basic information

• Product Name: 4β-chloroacetamido-4-deoxy-4′-desmethylepipdophyllotoxin
• Synonyms: 4β-chloroacetamido-4-deoxy-4′-desmethylepipdophyllotoxin
• CAS NO: 150059-96-4
• Molecular Weight: 475.883
• Mol File: 150059-96-4.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: 4β-chloroacetamido-4-deoxy-4′-desmethylepipdophyllotoxin(CAS DataBase Reference)
• NIST Chemistry Reference: 4β-chloroacetamido-4-deoxy-4′-desmethylepipdophyllotoxin(150059-96-4)
• EPA Substance Registry System: 4β-chloroacetamido-4-deoxy-4′-desmethylepipdophyllotoxin(150059-96-4)

Safety Data

• Hazardous Substances Data: 150059-96-4(Hazardous Substances Data)

Upstream product

• 107-14-2 chloroacetonitrile 
• 40505-27-9 4-demethylpodophyllotoxin 
• 6559-91-7 4'-demethylepipodophyllotoxin 

Downstream Products

• 117507-84-3 (5R,5aR,8aS,9S)-9-amino-5-(4-hydroxy-3,5-dimethoxyphenyl)-5,5a,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(8H)-one 
• 1134455-96-1 4β-amino-4′-desmethylepipdophyllotoxin hydrochloride 
• 1429193-54-3 C₂₇H₂₄N₂O₈S₂ 
• 1429193-53-2 C₂₇H₂₄N₂O₉S 
• 1278585-97-9 4β-[3-(4-chlorobenzoyl)thioureido]-4'-O-demethyl-4-desoxypodophyllotoxin 
• 1278585-93-5 4β-(3-benzoylthioureido)-4'-O-demethyl-4-desoxypodophyllotoxin 
• 1208364-57-1 4β-chloroacetamido-4'-demethyl-4'-benzyloxycarbonyl-4-deoxypodophyllotoxin 

Relevant articles and documents

Structure-based design, synthesis and biological testing of etoposide analog epipodophyllotoxin-N-mustard hybrid compounds designed to covalently bind to topoisomerase II and DNA

Drugs that target DNA topoisomerase II isoforms and alkylate DNA represent two mechanistically distinct and clinically important classes of anticancer drugs. Guided by molecular modeling and docking a series of etoposide analog epipodophyllotoxin-N-mustar

Structure-based design, synthesis and biological testing of piperazine-linked bis-epipodophyllotoxin etoposide analogs

Drugs that target DNA topoisomerase II, such as the epipodophyllotoxin etoposide, are a clinically important class of anticancer agents. A recently published X-ray structure of a ternary complex of etoposide, cleaved DNA and topoisomerase IIβ showed that

Design, synthesis and potent cytotoxic activity of novel podophyllotoxin derivatives

Twenty new acyl thiourea derivatives of podophyllotoxin and 4′-demethylepipodophyllotoxin were prepared and screened for their cytotoxicity against four human tumor cell lines, A-549, DU-145, KB, and KBvin. With IC50 values of 0.098-1.13 μM, co