117507-84-3Relevant articles and documents
Synthesis and evaluation of new podophyllotoxin derivatives with in vitro anticancer activity
Cheng, Wei-Hua,Shang, Hai,Niu, Cong,Zhang, Zhong-Heng,Zhang, Li-Ming,Chen, Hong,Zou, Zhong-Mei
, p. 12266 - 12279 (2015)
A series of novel podophyllotoxin derivatives were designed and synthesized. The cytotoxic activities of these compounds were tested against three tumor cell lines (HeLa, K562, and K562/A02). Most of the derivatives (IC50 = 1-20 μM) were found
A facile and efficient synthesis of 4β-aminopodophyliotoxins
Yu, Yong-Ping,Chen, Shao-Yuan,Wang, Yan-Guang,Chen, Yao-Zu
, p. 1967 - 1970 (1999)
4β-amino-4-desoxypodophyllotoxin and 4β-amino-4'-desmethyl-4- desoxypodophyllotoxin have been synthesized by reduction of the corresponding 4β-azidopodophyllotoxin derivatives with samarium diiodide in excellent yields under convenient and mild conditions.
Synthesis and antitumor activity of spin-labeled derivatives of podophyllotoxin
Tian, Xuan,Wang, Yan-Guang,Yang, Ming-Gui,Chen, Yao-Zu
, p. 511 - 517 (1997)
Three new nitroxyl labeled derivatives of podophyllotoxin 4-6 have been synthesized and evaluated for their antitumor activity in vitro. Compounds 4-6 showed significant inhibitory activity against human nasopharyngeal carcinoma KB, lung cancer A549 and s
HUMAN TOPOISOMERASE II-TARGETING ORGANOPLATINUM COMPOUNDS
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, (2020/03/15)
Some organoplatinum compounds have been synthesized. These organoplatinum compounds are designed to be human Topoisomerase II-targeting drugs.