150254-19-6Relevant articles and documents
Iron-catalyzed, highly regioselective synthesis of α-aryl carboxylic acids from styrene derivatives and CO2
Greenhalgh, Mark D.,Thomas, Stephen P.
, p. 11900 - 11903 (2012/09/07)
The iron-catalyzed hydrocarboxylation of aryl alkenes has been developed using a highly active bench-stable iron(II) precatalyst to give α-aryl carboxylic acids in excellent yields and with near-perfect regioselectivity. Using just 1 mol % FeCl2, bis(imino)pyridine 6 (1 mol %), CO 2 (atmospheric pressure), and a hydride source (EtMgBr, 1.2 equiv), a range of sterically and electronically differentiated aryl alkenes were transformed to the corresponding α-aryl carboxylic acids (up to 96% isolated yield). The catalyst was found to be equally active with a loading of 0.1 mol %. Preliminary mechanistic investigations show that an iron-catalyzed hydrometalation is followed by transmetalation and reaction with the electrophile (CO2).
Use of Formic or Oxalic Acid for the Regioselective Hydrocarboxylation of Alkenes and Alkynes Catalyzed by Pd/C and 1,4-Bis(diphenylphosphino)butane
Ali, B. El,Vasapollo, G.,Alper, H.
, p. 4739 - 4741 (2007/10/02)
-
