150360-26-2

Basic information

• Product Name: (2R)-2-(4-fluorophenyl)propanoic acid
• Synonyms: (2R)-2-(4-fluorophenyl)propanoic acid
• CAS NO: 150360-26-2
• Molecular Weight: 168.168
• EINECS: -0
• Mol File: 150360-26-2.mol
• Article Data: 14

Chemical Properties

• CAS DataBase Reference: (2R)-2-(4-fluorophenyl)propanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (2R)-2-(4-fluorophenyl)propanoic acid(150360-26-2)
• EPA Substance Registry System: (2R)-2-(4-fluorophenyl)propanoic acid(150360-26-2)

Safety Data

• Hazardous Substances Data: 150360-26-2(Hazardous Substances Data)

Usage

Description

(2R)-2-(4-fluorophenyl)propanoic acid is a chiral compound derived from propanoic acid, featuring a 4-fluorophenyl group attached to the second carbon atom. Its specific 2R configuration endows it with potential applications in various fields, particularly in pharmaceuticals and organic synthesis.

Uses

Used in Pharmaceutical Industry:
(2R)-2-(4-fluorophenyl)propanoic acid is used as a pharmaceutical compound for its potential anti-inflammatory and analgesic properties, offering therapeutic benefits in managing pain and inflammation.
Used in Organic Synthesis:
(2R)-2-(4-fluorophenyl)propanoic acid is used as a building block in the synthesis of various organic compounds, contributing to the development of new chemical entities with diverse applications.
Used in Fluorine Chemistry:
(2R)-2-(4-fluorophenyl)propanoic acid is used as a starting material for the synthesis of fluorinated compounds, capitalizing on the unique properties of fluorine to enhance the performance of resulting compounds in various chemical and pharmaceutical applications.

Upstream product

• 766-98-3 1-ethynyl-4-fluorobenzene 
• 64-18-6 formic acid 
• 189445-63-4 2-(4-fluorophenyl)propionaldehyde 
• 947383-48-4 (E)-1-fluoro-4-(1-nitroprop-1-en-2-yl)benzene 
• 350-40-3 2-(4-fluorophenyl)-1-propene 
• 403-42-9 1-(4-fluorophenyl)ethanone 
• 549532-50-5 2-(4-fluorophenyl)propanal 
• 405-99-2 para-fluorostyrene 
• 459-22-3 4-fluorophenylacetonitrile 
• 75908-73-5 (+/-)-2-(4-flurophenyl)propanoic acid 
• 2627-86-3 (S)-1-phenyl-ethylamine 
• 50415-71-9 methyl 2-(4-fluorophenyl)propanoate 
• 138485-30-0 2-(4-Fluoro-phenyl)-malonic acid dimethyl ester 
• 34837-84-8 4-fluorobenzeneacetic acid methyl ester 

Downstream Products

• 1443763-60-7 (2R)-2-(4-fluorophenyl)-N-[4-(2-{[2-methoxy-4-(methylsulfonyl)phenyl]amino}[1,2,4]triazolo[1,5,α]pyridin-6-yl)phenyl]propanamide 
• 1443763-62-9 (2R)-2-(4-fluorophenyl)-N-[4-(2-{[4-(methylsulfonyl)-2-(2,2,2-trifluoroethoxy)phenyl]amino}[1,2,4]triazolo[1,5-α]pyridin-6-yl)phenyl]propanamide 
• 1443763-63-0 4-{[6-(4-{[(2R)-2-(4-fluorophenyl)propanoyl]-amino}phenyl)[1,2,4]triazolo[1,5-a]pyridin-2-yl]amino}-3-methoxy-N-(2,2,2-trifluoroethyl)benzamide 
• 1443763-64-1 4-{[6-(4-{[(2R)-2-(4-fluorophenyl)propanoyl]amino}phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]amino}-3-methoxybenzamide 
• 1443763-65-2 4-{[6-(4-{[(2R)-2-(4-fluorophenyl)propanoyl]amino}phenyl)[1,2,4]triazolo[1,5-a]pyridin-2-yl]amino}-3-(2,2,2-trifluoroethoxy)benzamide 
• 1443763-66-3 (2R)-N-{4-[2-({4-[(3-fluoroazetidin-1-yl)carbonyl]-2-methoxyphenyl}amino)-[1,2,4]triazolo[1,5-α]pyridin-6-yl]phenyl}-2-(4-fluorophenyl)propanamide 
• 1443763-67-4 (2R)-N-[4-(2-{[4-(azetidin-1-ylcarbonyl)-2-methoxyphenyl]amino}[1,2,4]-triazolo[1,5-α]pyridin-6-yl)phenyl]-2-(4-fluorophenyl)propanamide 
• 1443763-68-5 (2R)-2-(4-fluorophenyl)-N-[4-(2-{[2-methoxy-4-(2-oxo-1,3-oxazolidin-3-yl)-phenyl]amino}[1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl]propanamide 
• 1443763-71-0 (2R)-2-amino-2-(4-fluorophenyl)-N-[4-(2-{[2-methoxy-4-(methylsulfonyl)-phenyl]amino}[1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl]ethanamide 
• 374898-01-8 (R)-1-(4-fluorophenyl)ethylamine 
• 1443763-72-1 4-{[6-(4-{[(2R)-2-(4-fluorophenyl)propanoyl]amino}phenyl)[1,2,4]triazolo[1,5-a]pyridin-2-yl]amino}-3-methoxy-N,N-dimethylbenzamide 
• 1443763-74-3 (2R)-N-{4-[2-({4-[(3-fluoroazetidin-1-yl)carbonyl]-2-(2,2,2-trifluoroethoxy)phenyl}amino)[1,2,4]triazolo[1,5-α]pyridin-6-yl]phenyl}-2-(4-fluorophenyl)propanamide 

Relevant articles and documents

Enantioselective Synthesis of Chiral Carboxylic Acids from Alkynes and Formic Acid by Nickel-Catalyzed Cascade Reactions: Facile Synthesis of Profens

We report a stereoselective conversion of terminal alkynes to α-chiral carboxylic acids using a nickel-catalyzed domino hydrocarboxylation-transfer hydrogenation reaction. A simple nickel/BenzP* catalyst displayed high activity in both steps of regioselective hydrocarboxylation of alkynes and subsequent asymmetric transfer hydrogenation. The reaction was successfully applied in enantioselective preparation of three nonsteroidal anti-inflammatory profens (>90 % ees) and the chiral fragment of AZD2716.

Substrate Scope Evaluation of the Enantioselective Reduction of β-Alkyl-β-arylnitroalkenes by Old Yellow Enzymes 1-3 for Organic Synthesis Applications

The substrate scope of the old yellow enzyme catalyzed reduction of β-alkyl-β-arylnitroalkenes is investigated. Compounds bearing either alkyl chains of increasing length at the carbon atom in position β to the nitro group or different substituents on the aromatic ring are prepared and submitted to bioreduction, to define the synthetic potential of this enantioselective reaction in the preparation of chiral fine chemicals. The versatility of the resulting nitroalkanes as chiral building blocks is shown by reducing the nitro group into a primary amine and by converting it into a carboxylic acid moiety by Meyer reaction. An "explosion" of chiral products can be observed by combining the highly enantioselective ene-reductase-mediated reduction of nitroalkenes with the chemical versatility of the nitro group.

Easily accessible TADDOL-derived bisphosphonite ligands: Synthesis and application in the asymmetric hydroformylation of vinylarenes

The synthesis of chiral bidentate bisphosphonite ligands based on the TADDOL motif from readily available starting materials has been developed. Taking advantage of the modular nature of the building blocks, a diverse ligand library has been prepared. Their catalytic potential has been evaluated in the asymmetric hydroformylation of styrene and derivatives. These catalysts showed high activity and provided the aldehydes in high enantiomeric purity.