150444-52-3

Basic information

• Product Name: (Z)-1-(4-Chloro-phenyl)-3-hydroxy-but-2-en-1-one
• CAS NO: 150444-52-3
• Molecular Weight: 196.633
• Mol File: 150444-52-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (Z)-1-(4-Chloro-phenyl)-3-hydroxy-but-2-en-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: (Z)-1-(4-Chloro-phenyl)-3-hydroxy-but-2-en-1-one(150444-52-3)
• EPA Substance Registry System: (Z)-1-(4-Chloro-phenyl)-3-hydroxy-but-2-en-1-one(150444-52-3)

Safety Data

• Hazardous Substances Data: 150444-52-3(Hazardous Substances Data)

Upstream product

• 150444-53-4 4-(4-chlorophenyl)-4-hydroxy-3-buten-2-one 
• 99-91-2 para-chloroacetophenone 
• 141-78-6 ethyl acetate 

Downstream Products

• 526220-86-0 (4-chloro-phenyl)-(7-ethoxy-3-methyl-4H-benzo[1,4]thiazin-2-yl)-methanone 
• 1243254-62-7 C₁₆H₁₀BrClFNO₃S 
• 1243254-58-1 C₁₆H₁₀BrClFNOS 
• 500169-20-0 2-(4-chlorophenyl)-6-morpholino-4H-thiopyran-4-one 
• 500169-90-4 6-(4-chlorophenyl)-2-ethylsulfanyl-4H-thiopyran-4-one 
• 150444-53-4 4-(4-chlorophenyl)-4-hydroxy-3-buten-2-one 
• 500169-97-1 6-(4-chlorophenyl)-2-mercapto-4H-thiopyran-4-one 
• 648415-92-3 (7-chloro-3-methyl-5-trifluoromethyl-4H-benzo[1,4]thiazin-2-yl)-(4-chloro-phenyl)-methanone 
• 110821-54-0 (4-Chloro-phenyl)-(5-fluoro-3-methyl-4H-benzo[1,4]thiazin-2-yl)-methanone 

Relevant articles and documents

Hypoxia-Sensitive Metal β-Ketoiminato Complexes Showing Induced Single-Strand DNA Breaks and Cancer Cell Death by Apoptosis

A series of ruthenium and iridium complexes have been synthesized and characterized with 20 novel crystal structures discussed. The library of β-ketoiminato complexes has been shown to be active against MCF-7 (human breast carcinoma), HT-29 (human colon carcinoma), A2780 (human ovarian carcinoma), and A2780cis (cisplatin-resistant human ovarian carcinoma) cell lines, with selected complexes' being more than three times as active as cisplatin against the A2780cis cell line. Selected complexes were also tested against the noncancerous ARPE-19 (retinal pigment epithelial cells) cell line, in order to evaluate the complexes selectivity for cancer cells. Complexes have also been shown to be highly active under hypoxic conditions, with the activities of some complexes increasing with a decrease in O2 concentration. The enzyme thioredoxin reductase is overexpressed in cancer cells, and complexes reported herein have the advantage of inhibiting this enzyme, with IC50 values measured in the nanomolar range. The anticancer activity of these complexes was further investigated to determine whether activity is due to effects on cellular growth or cell survival. The complexes were found to induce significant levels of cancer cell death by apoptosis with levels induced correlating closely with activity in chemosensitivity studies. As a possible cause of cell death, the ability of the complexes to induce damage to cellular DNA was also assessed. The complexes failed to induce double-strand DNA breaks or DNA cross-linking but induced significant levels of single-strand DNA breaks, indicating a mechanism of action different from that of cisplatin.

2,6-Disubstituted pyran-4-one and thiopyran-4-one inhibitors of DNA-dependent protein kinase (DNA-PK)

6-Aryl-2-morpholin-4-yl-4H-pyran-4-ones and 6-aryl-2-morpholin-4-yl-4H-thiopyran-4-ones were synthesised and evaluated as potential inhibitors of the DNA repair enzyme DNA-dependent protein kinase (DNA-PK). Several compounds in each series exhibited super