1507-88-6

Basic information

• Product Name: Benzene, (3-chloro-2-methyl-1-propenyl)-
• CAS NO: 1507-88-6
• Molecular Formula: C10H11Cl
• Molecular Weight: 166.65
• Mol File: 1507-88-6.mol
• Article Data: 12

Chemical Properties

• CAS DataBase Reference: Benzene, (3-chloro-2-methyl-1-propenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, (3-chloro-2-methyl-1-propenyl)-(1507-88-6)
• EPA Substance Registry System: Benzene, (3-chloro-2-methyl-1-propenyl)-(1507-88-6)

Safety Data

• Hazardous Substances Data: 1507-88-6(Hazardous Substances Data)

Upstream product

• 1504-55-8 2-methyl-3-phenylprop-2-en-1-ol 
• 15174-47-7 α-methyl-trans-cinnamaldehyde 
• 7042-33-3 ethyl (E)-2-methyl-3-phenyl-2-propenoate 
• 100-52-7 benzaldehyde 
• 1895-97-2 2-methyl-3-phenylacrylic acid 
• 1504-55-8 (E)-3-phenyl-2-methyl-2-propenol 
• 101-39-3 2-methyl-3-phenyl-2-propenal 
• 103729-80-2 2-methyl-1-phenylprop-2-en-1-ol 

Downstream Products

• 1504-55-8 2-methyl-3-phenylprop-2-en-1-ol 
• 97294-41-2 <(E)-2-methyl-3-phenyl-2-propenyl>hydrazine 
• 103729-80-2 2-methyl-1-phenylprop-2-en-1-ol 
• 30649-19-5 (E)-2-methyl-1-phenyl-1-pentene 
• 60428-21-9 (E)-(2-methylhex-1-enyl)benzene 
• 24347-61-3 (R)-1-phenyl-2-methyl-1,2-propanediol 

Relevant articles and documents

Photoenzymatic Synthesis of α-Tertiary Amines by Engineered Flavin-Dependent "ene"-Reductases

α-Tertiary amines are a common motif in pharmaceutically important molecules but are challenging to prepare using asymmetric catalysis. Here, we demonstrate engineered flavin-dependent ‘ene'-reductases (EREDs) can catalyze radical additions into oximes to prepare this motif. Two different EREDs were evolved into competent catalysts for this transformation with high levels of stereoselectivity. Mechanistic studies indicate that the oxime contributes to the enzyme templated charge-transfer complex formed between the substrate and cofactor. These products can be further derivatized to prepare a variety of motifs, highlighting the versatility of ERED photoenzymatic catalysis for organic synthesis.

METHOD OF CONVERTING ALCOHOL TO HALIDE

The present invention relates to a method of converting an alcohol into a corresponding halide. This method comprises reacting the alcohol with an optionally substituted aromatic carboxylic acid halide in presence of an N-substituted formamide to replace a hydroxyl group of the alcohol by a halogen atom. The present invention also relates to a method of converting an alcohol into a corresponding substitution product. The second method comprises: (a) performing the method of the invention of converting an alcohol into the corresponding halide; and (b) reacting the corresponding halide with a nucleophile to convert the halide into the nucleophilic substitution product.

Controlling 6-endo-selectivity in oxidation/bromocyclization cascades for synthesis of aplysiapyranoids and other 2,2,6,6-substituted tetrahydropyrans

A cascade, composed of (i) oxovanadium(V)-catalyzed oxidation of bromide by tert-butyl hydroperoxide and (ii) stereoselective 6-endo-bromocyclization, affords 3-bromo-2-aryl-2,6,6-trimethyltetrahydropyrans from styrene-type tertiary alkenols in synthetically useful yields. (E)-Alkenols add the bromo- and the alkoxy substituent anti-selectively across the double bond, indicating a bromonium ion-mechanism for the ring closure. 6-endo-control of the alkenol cyclization thereby arises from the polar effect of the aryl substituent. Two methyl substituents bound to the alkene terminus are not similarly able to favor 6-endo-cyclization, because strain arising from methyl group repulsion, as the bromonium-activated π-bond and the hydroxyl oxygen approach, directs bromocyclization of tertiary prenyl-type substrates toward tetrahydrofuran formation. A hexasubstituted bromotetrahydropyran prepared from the oxidation/bromocyclization cascade served as starting material for synthesis of racemic aplysiapyranoid A, in a sequence of free radical and polar functional group interconversion.