151039-11-1Relevant articles and documents
Towards the total synthesis of the anti-trypanosomal macrolide, Actinoallolides: Construction of a key linear intermediate
Oshita, Jun,Noguchi, Yoshihiko,Watanabe, Akito,Sennari, Goh,Sato, Shogo,Hirose, Tomoyasu,Oikawa, Daiki,Inahashi, Yuki,Iwatsuki, Masato,Ishiyama, Aki,Omura, Satoshi,Sunazuka, Toshiaki
, p. 357 - 360 (2016)
Herein, we describe the synthesis of key intermediate (+)-8 as an essential intermediate including full carbon framework for completing the convergent total synthesis of Actinoallolide A (1). (+)-8 was obtained by Negishi and Stille cross coupling from (+)-9, (+)-10 and (-)-11. Stereo-divergent preparation of two similar units, consisting of three consecutive stereocenters, facilitated the synthesis of (+)-10 and (-)-11.
Counterattack mode differential acetylative deprotection of phenylmethyl ethers: Applications to solid phase organic reactions
Chakraborti, Asit K.,Chankeshwara, Sunay V.
supporting information; experimental part, p. 1367 - 1370 (2009/07/04)
A counterattack protocol for differential acetylative cleavage of phenylmethyl ether has been developed. The phenylmethyl moiety is liberated as benzyl bromide that is isolated and reused providing advantages in terms of waste minimization/utilization and atom economy. The applicability of this methodology has been extended for solid phase organic reactions with the feasibility of reuse of the solid support.
