61552-31-6Relevant articles and documents
Towards the total synthesis of the anti-trypanosomal macrolide, Actinoallolides: Construction of a key linear intermediate
Oshita, Jun,Noguchi, Yoshihiko,Watanabe, Akito,Sennari, Goh,Sato, Shogo,Hirose, Tomoyasu,Oikawa, Daiki,Inahashi, Yuki,Iwatsuki, Masato,Ishiyama, Aki,Omura, Satoshi,Sunazuka, Toshiaki
, p. 357 - 360 (2016/01/12)
Herein, we describe the synthesis of key intermediate (+)-8 as an essential intermediate including full carbon framework for completing the convergent total synthesis of Actinoallolide A (1). (+)-8 was obtained by Negishi and Stille cross coupling from (+)-9, (+)-10 and (-)-11. Stereo-divergent preparation of two similar units, consisting of three consecutive stereocenters, facilitated the synthesis of (+)-10 and (-)-11.